Phenotypes associated with this allele

• Allele Symbol: Scn10a^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:4430300
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scn10a^tm1Lex/Scn10a^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:4430302

Genotype
MGI:4430302

hm1

• Allelic Composition: Scn10a^tm1Lex/Scn10a^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal pain threshold ( J:157013 )

• fail to show significant changes in mechanical pain thresholds after injection of complete Freund's adjuvant

hyperalgesia ( J:157013 )

• complete Freund's adjuvant injected mice recover from thermal hyperalgesia within 48 hours whereas wild-type injected mice do not

nervous system

abnormal action potential ( J:157066 )

• the peak amplitude reached in neurons that develop full action potentials is significantly lower

• neither the rheobase of the neurons nor the number of action potentials they fire at 2x rheobase are altered by Nippostrongylus brasiliensis infection

impaired ability to fire action potentials ( J:157066 )

• only 66% of neurons exhibit full action potentials