All Phenotypes Irs1<tm2.1Mfw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Irs1^tm2.1Mfw
targeted mutation 2.1, Morris F White
MGI:4430350

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Irs1^tm2.1Mfw/Irs1^tm2.1Mfw	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	MGI:4430355
ht2	Irs1^tm2.1Mfw/Irs1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	MGI:4430354
cn3	Irs1^tm1Mfw/Irs1^tm2.1Mfw Irs2^tm2Mfw/Irs2^tm2Mfw Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N	MGI:4430356
cn4	Irs1^tm2.1Mfw/Irs1^tm2.1Mfw Irs2^tm2Mfw/Irs2^tm2Mfw Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N	MGI:4430358

Allelic Composition	Irs1^tm2.1Mfw/Irs1^tm2.1Mfw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1^tm2.1Mfw mutation (0 available); any Irs1 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:156999 )

• slightly

decreased body length ( J:156999 )

• slightly

homeostasis/metabolism

increased circulating insulin level ( J:156999 )

• the median fasting plasma insulin is higher

• high-fat diet fed mice have a median fasting insulin concentrations that is substantially elevated over that of wild-type mice

impaired glucose tolerance ( J:156999 )

• high-fat diet fed mice are significantly glucose intolerant

insulin resistance ( J:156999 )

• in an insulin tolerance test the maximum drop in blood glucose at 60 minutes is significantly less than in wild-type mice

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:156999 )

• pancreatic beta cell area increases significantly in high-fat diet fed mice

Allelic Composition	Irs1^tm2.1Mfw/Irs1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1^tm2.1Mfw mutation (0 available); any Irs1 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:156999 )

• pancreatic beta cell area increases significantly in high-fat diet fed mice

homeostasis/metabolism

increased circulating insulin level ( J:156999 )

• high-fat diet fed mice have a median fasting insulin concentration that is substantially elevated over that of wild-type mice

Allelic Composition	Irs1^tm1Mfw/Irs1^tm2.1Mfw Irs2^tm2Mfw/Irs2^tm2Mfw Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1^tm1Mfw mutation (0 available); any Irs1 mutation (52 available)
Irs1^tm2.1Mfw mutation (0 available); any Irs1 mutation (52 available)
Irs2^tm2Mfw mutation (0 available); any Irs2 mutation (37 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating insulin level ( J:156999 )

• fasting and fed insulin concentrations are elevated

impaired glucose tolerance ( J:156999 )

• severe glucose intolerance

insulin resistance ( J:156999 )

• significant insulin resistance

Allelic Composition	Irs1^tm2.1Mfw/Irs1^tm2.1Mfw Irs2^tm2Mfw/Irs2^tm2Mfw Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1^tm2.1Mfw mutation (0 available); any Irs1 mutation (52 available)
Irs2^tm2Mfw mutation (0 available); any Irs2 mutation (37 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating insulin level ( J:156999 )

• fasting insulin concentration are elevated

impaired glucose tolerance ( J:156999 )

• significantly glucose intolerant

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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