Phenotypes associated with this allele

• Allele Symbol: Gsta3^tm1Sell
• Allele Name: targeted mutation 1, Stewart Sell
• Allele ID: MGI:4430389
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gsta3^tm1Sell/Gsta3^tm1Sell	C57BL/6-Gsta3^tm1Sell	MGI:4430390

Genotype
MGI:4430390

hm1

• Allelic Composition: Gsta3^tm1Sell/Gsta3^tm1Sell
• Genetic Background: C57BL/6-Gsta3^tm1Sell

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:157029 )

• following 5 mg/kg aflatoxin injection, all mice die due to massive liver necrosis compared to no death in wild-type mice

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:157029 )

• following 5 mg/kg aflatoxin injection, all mice die due to massive liver necrosis compared to no death in wild-type mice

increased physiological sensitivity to xenobiotic ( J:157029 )

• aflatoxin (AFB1) treated mice form 100-fold more AFB1-N7-guanine adducts

• three hours after AFB1 administration, some areas of the livers show loss of hepatocyte cell borders, and pyknotic nuclei