Analysis Tools
nervous system
|
• mice show normal myelination at P15, however axons of peripheral nerves are hypermyelinated by P90
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice show normal myelination at P15, however axons of peripheral nerves are hypermyelinated by P90
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice lack mature BCR positive B cells
|
|
• mice lack mature BCR positive B cells
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• at P15, the myelin of peripheral axons is thinner but axons are hypermyelinated at P90
|
|
• at P15 and P90, 36.7% and 17.8% of axons with diameters >1 um are nonmyelinated, respectively compared to 3.5% and 0.8% in controls
|
|
• axons are hypermyelinated at P90
• however, mice show rescue of Schwann cell development and Schwan cells are able to myelinate
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• axons of peripheral nerves are hypermyelinated at P90
• however, mice show normal numbers of Schwann cells
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• onion bulb structures are seen indicating myelin degeneration and regeneration
• however, stacking of myelin sheaths in compact myelin is unaffected
• noncompact myelin structures are more abundant
|
|
• myelin sheaths are thicker at P15 and P30 and myelin continues to grow radially such that the mean myelin area in peripheral nerves at P90 is increased 6-fold
• increase in myelin thickness is particularly pronounced in small-diameter fibers
|
|
• increase in the diameter of sciatic nerves due to massive hypermyelination and reduced axonal packing
|
|
• myelination begins prematurely and mice show continuous myelin growth
• increase in the number of myelinated fibers per field at P0
• myelin abnormalities are seen at P30-P90 but not at P15, indicating that they result from massive hypermylination
• treatment with the mTORC1 inhibitor everolimus dampens myelin growth in the nerves of mutants and completely rescues the decreased axonal packing
|
|
• ratio of compound action potentials in myelinated A and nonmyelinated C fibers (A/C fiber waves) is reduced and there is a reduction in numbers of active mechanoreceptive units after P60 indicating that many myelinated axons are not conducting
|
|
• D-hair mechanoreceptors show increased conduction velocities at P30, however no differences were seen after P60
• however, conduction velocities of other mechanosensory fibers are unchanged
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• constitutively active Map2k1(MEK) rescues thymocyte development restoring single positive thymocyte and splenic T cell populations
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• rarely observe aberrantly myelinated small axons in mutants and the ratio of nonmyelinated to myelinated axons is unchanged
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 09/03/2024 MGI 6.24 |
|
|
|
||