Phenotypes associated with this allele

• Allele Symbol: Esr1^tm1.1Scma
• Allele Name: targeted mutation 1.1, Stavros C Manolagas
• Allele ID: MGI:4430564
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Esr1^tm1.1Scma/Esr1^tm1.1Scma Lyz2^tm1(cre)Ifo/Lyz2^+	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6	MGI:4430565

Genotype
MGI:4430565

cn1

• Allelic Composition: Esr1^tm1.1Scma/Esr1^tm1.1Scma; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

increased osteoclast cell number ( J:156947 )

• in vertebral cancellous bone at 12 weeks of age

abnormal osteoclast physiology ( J:156947 )

• 17beta-estradiol has no effect on osteoclast apoptosis unlike in wild-type mice

decreased compact bone mass ( J:156947 )

• after ovariectomy mice lose cortical bone mass but not cancellous bone mass

abnormal trabecular bone morphology ( J:156947 )

• increase in the number of osteoclasts in vertebral cancellous bone at 12 weeks of age

• at 28 weeks of age, but not at 12 weeks, bone mass is reduced, trabecular width is decreased, and trabecular separation is increased in vertebral cancellous bone

abnormal skeleton development ( J:156947 )

• the number of osteoclast progenitors is increased 2 fold at 12 weeks of age

hematopoietic system

increased osteoclast cell number ( J:156947 )

• in vertebral cancellous bone at 12 weeks of age

abnormal osteoclast physiology ( J:156947 )

• 17beta-estradiol has no effect on osteoclast apoptosis unlike in wild-type mice

immune system

increased osteoclast cell number ( J:156947 )

• in vertebral cancellous bone at 12 weeks of age

abnormal osteoclast physiology ( J:156947 )

• 17beta-estradiol has no effect on osteoclast apoptosis unlike in wild-type mice