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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Col1a1tm1(CAG-Sirt1)Dsin
targeted mutation 1, David Sinclair
MGI:4430570
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		ApcMin/Apc+
Col1a1tm1(CAG-Sirt1)Dsin/Col1a1+
Tg(Vil1-cre)997Gum/0 		involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL MGI:4430578
cx2
 		ApcMin/Apc+
Col1a1tm1(CAG-Sirt1)Dsin/Col1a1+ 		involves: 129S4/SvJae * C57BL/6 * C57BL/6J MGI:4430577


Genotype
MGI:4430578
cn1
Allelic
Composition		 ApcMin/Apc+
Col1a1tm1(CAG-Sirt1)Dsin/Col1a1+
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Col1a1tm1(CAG-Sirt1)Dsin mutation (1 available); any Col1a1 mutation (163 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor incidence ( J:134301 )
• mice do not develop tumors morbidities, including anemia and cachaxia, unlike Col1a1tm1(CAG-Sirt1)Dsin ApcMin heterozygotes
• mice develop fewer intestinal tumors than Col1a1tm1(CAG-Sirt1)Dsin ApcMin heterozygotes




Genotype
MGI:4430577
cx2
Allelic
Composition		 ApcMin/Apc+
Col1a1tm1(CAG-Sirt1)Dsin/Col1a1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Col1a1tm1(CAG-Sirt1)Dsin mutation (1 available); any Col1a1 mutation (163 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased gastrointestinal tumor incidence ( J:134301 )
• mice develop intestinal tumors in the duodenum and ileum

growth/size/body
cachexia ( J:134301 )
• at 16 weeks

hematopoietic system
anemia ( J:134301 )
• at 16 weeks

digestive/alimentary system
increased gastrointestinal tumor incidence ( J:134301 )
• mice develop intestinal tumors in the duodenum and ileum




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory