All Phenotypes Trp53<tm6Xu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trp53^tm6Xu
targeted mutation 6, Yang Xu
MGI:4430743

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Trp53^tm6Xu/Trp53^tm6Xu Tg(Lck-cre)1Cwi/0	involves: 129S4/SvJae	MGI:4430744

Allelic Composition	Trp53^tm6Xu/Trp53^tm6Xu Tg(Lck-cre)1Cwi/0
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-cre)1Cwi mutation (3 available)
Trp53^tm6Xu mutation (0 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:157041 )

• all die of tumors by 50 weeks of age

neoplasm

increased metastatic potential ( J:157041 )

• unlike in thymocyte conditional null mice (carrying Trp53^tm1Brd and Tg(Lck-cre)1Cwi ), about 40% of tumors are metastatic

increased lymphoma incidence ( J:157041 )

• predominantly peripheral and thymic lymphomas by 50 weeks of age

increased T cell derived lymphoma incidence ( J:157041 )

• by 50 weeks of age

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:157041 )

• by 50 weeks of age

hematopoietic system

increased T cell derived lymphoma incidence ( J:157041 )

• by 50 weeks of age

immune system

increased T cell derived lymphoma incidence ( J:157041 )

• by 50 weeks of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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