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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kitltm2.1Pbes
targeted mutation 2.1, Peter Besmer
MGI:4430867
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kitltm2.1Pbes/Kitltm2.1Pbes involves: 129S1/Sv * C57BL/6J * FVB/N MGI:4430869
ht2
 		Kitltm2.1Pbes/KitlSl involves: 129S1/Sv * C3H * C57BL/6J * FVB/N MGI:4430870


Genotype
MGI:4430869
hm1
Allelic
Composition		 Kitltm2.1Pbes/Kitltm2.1Pbes
Genetic
Background		 involves: 129S1/Sv * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitltm2.1Pbes mutation (0 available); any Kitl mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased testis weight ( J:157170 )
• 50% reduction compared to wild-type
• normal spermatogenesis by histological analysis

cellular
decreased cell proliferation ( J:157170 )
• reduced BrdU incorporation in the adult testis
• distinct patches of PCNA-absent regions in the adult testis

hematopoietic system
abnormal common myeloid progenitor cell morphology ( J:157170 )
• increased clonogenic mast cell progenitors
increased mast cell number ( J:157170 )
• increased mast cell numbers per centimeter skin compared to wild-type as assessed by toluidine blue staining
• increased peritoneal mast cell numbers

endocrine/exocrine glands
decreased testis weight ( J:157170 )
• normal spermatogenesis by histological analysis
• 50% reduction compared to wild-type

immune system
increased mast cell number ( J:157170 )
• increased mast cell numbers per centimeter skin compared to wild-type as assessed by toluidine blue staining
• increased peritoneal mast cell numbers




Genotype
MGI:4430870
ht2
Allelic
Composition		 Kitltm2.1Pbes/KitlSl
Genetic
Background		 involves: 129S1/Sv * C3H * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitlSl mutation (3 available); any Kitl mutation (94 available)
Kitltm2.1Pbes mutation (0 available); any Kitl mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
azoospermia ( J:157170 )
• absence of developing germ cells in the testis and mature sperm in the epididymis in adult mice
• morphologically normal testes at 4 week old

pigmentation

integument

cellular
azoospermia ( J:157170 )
• absence of developing germ cells in the testis and mature sperm in the epididymis in adult mice
• morphologically normal testes at 4 week old




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory