All Phenotypes Grhl3<tm1(cre)Cgh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Grhl3^tm1(cre)Cgh
targeted mutation 1, Shaun R Coughlin
MGI:4430902

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grhl3^tm1(cre)Cgh/Grhl3^tm1(cre)Cgh	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:4431051
cn2	Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2Cgh/Gna13^tm2Cgh Grhl3^tm1(cre)Cgh/Grhl3⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL	MGI:4438090
cn3	Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺ Rac1^tm1Djk/Rac1^tm1Djk	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL	MGI:4438086
cn4	Gna13^tm2Cgh/Gna13^tm2Cgh Grhl3^tm1(cre)Cgh/Grhl3⁺	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL	MGI:4431052
cn5	Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:4431053
cn6	Gnaz^tm1Lfb/Gnaz^tm1Lfb Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:4438084
cn7	Gnaz^tm1Lfb/Gnaz⁺ Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:4438085
cx8	Grhl3^tm1(cre)Cgh/Grhl3⁺ Usp39^em1Imat/Usp39⁺	involves: 129P2/OlaHsd * CD-1	MGI:7287462
cx9	Grhl3^tm1(cre)Cgh/Grhl3^tm1(cre)Cgh Usp39^em1Imat/Usp39⁺	involves: 129P2/OlaHsd * CD-1	MGI:7287463

Allelic Composition	Grhl3^tm1(cre)Cgh/Grhl3^tm1(cre)Cgh
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal neural tube morphology ( J:157446 )

• neural tube phenotypes are stated to be identical to that of Grhl3^tm1Jane homozygotes; however no data are presented

spina bifida ( J:157446 )

nervous system

abnormal neural tube morphology ( J:157446 )

• neural tube phenotypes are stated to be identical to that of Grhl3^tm1Jane homozygotes; however no data are presented

spina bifida ( J:157446 )

abnormal brain development ( J:157446 )

exencephaly ( J:157446 )

Allelic Composition	Gna12^tm1Citb/Gna12^tm1Citb Gna13^tm2Cgh/Gna13^tm2Cgh Grhl3^tm1(cre)Cgh/Grhl3⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12^tm1Citb mutation (0 available); any Gna12 mutation (23 available)
Gna13^tm2Cgh mutation (0 available); any Gna13 mutation (12 available)
Grhl3^tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:157446 )

• mutants die by 10.5 days post coitus (dpc)

embryo

abnormal embryo development ( J:157446 )

• embryos display turning defects and other defects, but the hindbrain neuropore is closed in mutants at 10.5 dpc

abnormal embryo turning ( J:157446 )

• embryos show turning defects

Allelic Composition	Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺ Rac1^tm1Djk/Rac1^tm1Djk
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)
Gt(ROSA)26Sor^tm1(ptxA)Cgh mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Rac1^tm1Djk mutation (1 available); any Rac1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

spina bifida ( J:157446 )

• observed in about 58% of viable embryos collected at 14.5 days post coitus

• folate injections performed on pregnant females does not affect penetrance

nervous system

spina bifida ( J:157446 )

• observed in about 58% of viable embryos collected at 14.5 days post coitus

• folate injections performed on pregnant females does not affect penetrance

exencephaly ( J:157446 )

• observed with around 83% frequency in viable embryos collected at 14.5 days post coitus

• folate injections performed on pregnant females does not affect penetrance

Allelic Composition	Gna13^tm2Cgh/Gna13^tm2Cgh Grhl3^tm1(cre)Cgh/Grhl3⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna13^tm2Cgh mutation (0 available); any Gna13 mutation (12 available)
Grhl3^tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:157446 )

N	• embryos live through 14.5 days post coitus

nervous system

nervous system phenotype ( J:157446 )

N	• exencephaly is not observed in mutant embryos through E14.5

Allelic Composition	Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal neural tube closure ( J:157446 )

• some embryos have open hindbrain neuropores, but open posterior neuropores (spina bifida) are not seen

nervous system

abnormal neural tube closure ( J:157446 )

• some embryos have open hindbrain neuropores, but open posterior neuropores (spina bifida) are not seen

exencephaly ( J:157446 )

• observed with 10% frequency in viable embryos collected at 14.5 days post coitus

Allelic Composition	Gnaz^tm1Lfb/Gnaz^tm1Lfb Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnaz^tm1Lfb mutation (1 available); any Gnaz mutation (18 available)
Grhl3^tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)
Gt(ROSA)26Sor^tm1(ptxA)Cgh mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

spina bifida ( J:157446 )

• observed in about 40% of embryos collected at 14.5 days post coitus

nervous system

spina bifida ( J:157446 )

• observed in about 40% of embryos collected at 14.5 days post coitus

exencephaly ( J:157446 )

• observed with 20% frequency at 14.5 days post coitus; no embryos

Allelic Composition	Gnaz^tm1Lfb/Gnaz⁺ Grhl3^tm1(cre)Cgh/Grhl3⁺ Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

spina bifida ( J:157446 )

• observed in about 18% of viable embryos collected at 14.5 days post coitus

exencephaly ( J:157446 )

• observed with around 4% frequency in viable embryos collected at 14.5 days post coitus

embryo

spina bifida ( J:157446 )

• observed in about 18% of viable embryos collected at 14.5 days post coitus

Allelic Composition	Grhl3^tm1(cre)Cgh/Grhl3⁺ Usp39^em1Imat/Usp39⁺
Genetic Background	involves: 129P2/OlaHsd * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3^tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)
Usp39^em1Imat mutation (0 available); any Usp39 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal hair growth ( J:324183 )

• hair fails to grow on thickened scaly skin

scaly skin ( J:324183 )

• thickened scaly skin in some mice

thick skin ( J:324183 )

• thickened scaly skin in some mice

Allelic Composition	Grhl3^tm1(cre)Cgh/Grhl3^tm1(cre)Cgh Usp39^em1Imat/Usp39⁺
Genetic Background	involves: 129P2/OlaHsd * CD-1

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

failure of eyelid fusion ( J:324183 )

• at increased frequency compared with Grhl3^tm1(cre)Cgh homozygotes at E15.5

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