Analysis Tools
growth/size/body
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• total body weights of males are equivalent to wild-type males
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reproductive system
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• tubules with smaller diameters are observed at 9 weeks
• at 9 weeks total Sertoli cell numbers are same as in controls
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• at 9 weeks, interstitial Leydig cells display hypertrophy and accumulation of lipid droplets
• at 9 weeks adult Leydig cells are present in testes
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• Leydig cells display hypertrophy at 9 weeks
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• at 5 or 10 days, testis weights are normal, but testis weights at 3 weeks are significantly lower (17.9 mg) than control males (24.9-27 mg)
• at 9 weeks of age, testis weight are significantly lower than in controls but are 51% higher than in Tg(AMH-cre)1Flor/ Artm1Jdz double mutants
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• testes display more post meiotic development than hemizygous transgenic cre/Ar mutant mice, with elongated spermatids and lumen present in some tubules
• clusters of cells resembling abnormal round spermatids and spermatozoa are present in ducts of rete testes, indicating premature detachment of postmeiotic cells from germinal epithelium
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endocrine/exocrine glands
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• tubules with smaller diameters are observed at 9 weeks
• at 9 weeks total Sertoli cell numbers are same as in controls
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• at 9 weeks, interstitial Leydig cells display hypertrophy and accumulation of lipid droplets
• at 9 weeks adult Leydig cells are present in testes
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• Leydig cells display hypertrophy at 9 weeks
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• at 5 or 10 days, testis weights are normal, but testis weights at 3 weeks are significantly lower (17.9 mg) than control males (24.9-27 mg)
• at 9 weeks of age, testis weight are significantly lower than in controls but are 51% higher than in Tg(AMH-cre)1Flor/ Artm1Jdz double mutants
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