Analysis Tools|
Allele Symbol Allele Name Allele ID |
Insl6tm1Imad targeted mutation 1, Ibrahim M Adham MGI:4431170 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• female mice are fertile
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• at P20 and P25 without chromosome pairing abnormalities
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• at P20 and P25 without chromosome pairing abnormalities
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• sperm motility and progressive motility are decreased in sperm from infertile mice compared to in wild-type mice
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• infertile mice exhibit reduced testis weight compared with wild-type mice
• testes from 15-, 20-, and 25-day old mice are reduced in weight compared to in wild-type mice
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• immature germ cells are prematurely released into the seminiferous epithelium unlike wild-type mice
• at P15, seminiferous tubules contain only Sertoli cells and spermatogonia unlike in wild-type mice
• at P20, progression of spermatogenesis is delayed compared to in wild-type mice
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• some mice lack late meiotic and post-meiotic germ cells
• at P25, germ cells are severely depleted compared to in wild-type mice
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• some mice exhibit a decrease in late meiotic and post-meiotic germ cells compared with wild-type mice
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• from male, but not female, mice
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• some male mice
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• some male mice
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• infertile mice exhibit reduced testis weight compared with wild-type mice
• testes from 15-, 20-, and 25-day old mice are reduced in weight compared to in wild-type mice
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• at P20 and P25 without chromosome pairing abnormalities
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• some mice lack late meiotic and post-meiotic germ cells
• at P25, germ cells are severely depleted compared to in wild-type mice
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• some mice exhibit a decrease in late meiotic and post-meiotic germ cells compared with wild-type mice
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• at P20 and P25 without chromosome pairing abnormalities
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• sperm motility and progressive motility are decreased in sperm from infertile mice compared to in wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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