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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ripk3tm1Xidw
targeted mutation 1, Xiaodong Wang
MGI:4431195
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ripk3tm1Xidw/Ripk3tm1Xidw involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4431201
hm2
 		Ripk3tm1Xidw/Ripk3tm1Xidw involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl MGI:6693622
cx3
 		Casp8em1Hbz/Casp8em1Hbz
Ripk3tm1Xidw/Ripk3tm1Xidw 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:7573088
cx4
 		Casp8em1Hbz/Casp8em1Hbz
Ripk1em4Hbz/Ripk1em4Hbz
Ripk3tm1Xidw/Ripk3tm1Xidw 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:7573096
cx5
 		Casp8em1Hbz/Casp8em1Hbz
Ripk1em1Hbz/Ripk1em1Hbz
Ripk3tm1Xidw/Ripk3tm1Xidw 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:7573098
cx6
 		Csnk1g2em1Xidw/Csnk1g2em1Xidw
Ripk3tm1Xidw/Ripk3tm1Xidw 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl MGI:6693623


Genotype
MGI:4431201
hm1
Allelic
Composition		 Ripk3tm1Xidw/Ripk3tm1Xidw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripk3tm1Xidw mutation (0 available); any Ripk3 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased susceptibility to induced pancreatitis ( J:157346 )
• cerulein-treated mice fail to exhibit pancreas acinar cell loss and necrosis unlike similarly treated wild-type mice

cellular
decreased sensitivity to induced cell death ( J:157346 )
• Trail plus Smac-, TNF-a/Smac mimetic/z-VAD-, or TRAIL/Smac mimetic/z-VAD-treated mouse embryonic fibroblasts (MEFs) fail to undergo cell death (apoptosis or necrosis) unlike similarly treated wild-type mice
• however, MEFs undergo apoptosis following treatment with TNF-a plus cycloheximide




Genotype
MGI:6693622
hm2
Allelic
Composition		 Ripk3tm1Xidw/Ripk3tm1Xidw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripk3tm1Xidw mutation (0 available); any Ripk3 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to induced morbidity/mortality ( J:298682 )
• mice are totally resistant to TNF-induced lethality




Genotype
MGI:7573088
cx3
Allelic
Composition		 Casp8em1Hbz/Casp8em1Hbz
Ripk3tm1Xidw/Ripk3tm1Xidw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8em1Hbz mutation (0 available); any Casp8 mutation (43 available)
Ripk3tm1Xidw mutation (0 available); any Ripk3 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased granulocyte number ( J:342732 )
• increased CD11b+ granulocytes in spleen
• normal in bone marrow
increased CD11b-high dendritic cell number ( J:342732 )
• increased percentage of myeloid-derived CD11b+ cells in spleen and bone marrow
increased macrophage cell number ( J:342732 )
• in spleen
• normal in bone marrow
decreased leukocyte cell number ( J:342732 )
• decreased white blood cell number in peripheral blood
• normal monocyte and granulocyte numbers in peripheral blood
decreased lymphocyte cell number ( J:342732 )
• in peripheral blood
decreased B cell number ( J:342732 )
• severe reduction in CD19+ B cell numbers in spleen, bone marrow and peripheral blood
decreased mature B cell number ( J:342732 )
• reduced B220+ IgM+ and B220+ CD19+ B cell numbers in spleen, bone marrow and peripheral blood
decreased T cell number ( J:342732 )
• severe reduction in CD3+ T cell numbers in spleen, bone marrow and peripheral blood
• severe reduction in CD3+ CD4+ CD8- and CD3+ CD4- CD8+ T cell in spleen, bone marrow and peripheral blood

hematopoietic system
increased granulocyte number ( J:342732 )
• increased CD11b+ granulocytes in spleen
• normal in bone marrow
increased CD11b-high dendritic cell number ( J:342732 )
• increased percentage of myeloid-derived CD11b+ cells in spleen and bone marrow
increased macrophage cell number ( J:342732 )
• in spleen
• normal in bone marrow
decreased leukocyte cell number ( J:342732 )
• decreased white blood cell number in peripheral blood
• normal monocyte and granulocyte numbers in peripheral blood
decreased lymphocyte cell number ( J:342732 )
• in peripheral blood
decreased B cell number ( J:342732 )
• severe reduction in CD19+ B cell numbers in spleen, bone marrow and peripheral blood
decreased mature B cell number ( J:342732 )
• reduced B220+ IgM+ and B220+ CD19+ B cell numbers in spleen, bone marrow and peripheral blood
decreased T cell number ( J:342732 )
• severe reduction in CD3+ T cell numbers in spleen, bone marrow and peripheral blood
• severe reduction in CD3+ CD4+ CD8- and CD3+ CD4- CD8+ T cell in spleen, bone marrow and peripheral blood

growth/size/body
enlarged spleen ( J:342732 )




Genotype
MGI:7573096
cx4
Allelic
Composition		 Casp8em1Hbz/Casp8em1Hbz
Ripk1em4Hbz/Ripk1em4Hbz
Ripk3tm1Xidw/Ripk3tm1Xidw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8em1Hbz mutation (0 available); any Casp8 mutation (43 available)
Ripk1em4Hbz mutation (0 available); any Ripk1 mutation (31 available)
Ripk3tm1Xidw mutation (0 available); any Ripk3 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:342732 )

integument
skin lesions ( J:342732 )
• focal cutaneous lesions

mortality/aging




Genotype
MGI:7573098
cx5
Allelic
Composition		 Casp8em1Hbz/Casp8em1Hbz
Ripk1em1Hbz/Ripk1em1Hbz
Ripk3tm1Xidw/Ripk3tm1Xidw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8em1Hbz mutation (0 available); any Casp8 mutation (43 available)
Ripk1em1Hbz mutation (0 available); any Ripk1 mutation (31 available)
Ripk3tm1Xidw mutation (0 available); any Ripk3 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased leukocyte cell number ( J:342732 )
• decreased white blood cell number in peripheral blood
• normal monocyte and granulocyte numbers in peripheral blood
decreased lymphocyte cell number ( J:342732 )
• in peripheral blood
decreased mature B cell number ( J:342732 )
• reduced B220+ IgM+ and B220+ CD19+ B cell numbers in spleen and bone marrow
decreased T cell number ( J:342732 )
• severe reduction in CD3+ CD4+ CD8- and CD3+ CD4- CD8+ T cell in spleen and bone marrow

immune system
decreased leukocyte cell number ( J:342732 )
• decreased white blood cell number in peripheral blood
• normal monocyte and granulocyte numbers in peripheral blood
decreased lymphocyte cell number ( J:342732 )
• in peripheral blood
decreased mature B cell number ( J:342732 )
• reduced B220+ IgM+ and B220+ CD19+ B cell numbers in spleen and bone marrow
decreased T cell number ( J:342732 )
• severe reduction in CD3+ CD4+ CD8- and CD3+ CD4- CD8+ T cell in spleen and bone marrow




Genotype
MGI:6693623
cx6
Allelic
Composition		 Csnk1g2em1Xidw/Csnk1g2em1Xidw
Ripk3tm1Xidw/Ripk3tm1Xidw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csnk1g2em1Xidw mutation (0 available); any Csnk1g2 mutation (37 available)
Ripk3tm1Xidw mutation (0 available); any Ripk3 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:298682 )
N
• double mutant males show significant rescue of the accelerated male reproductive system aging phenotype seen in single Csnk1g2em1Xidw male homozygotes at 12 months of age
• all physical signs of premature aging, including body weight gain, increase in seminal vesicle weight and decrease in testis weight, are mitigated, the % of empty seminiferous tubules drops to 2% while the necroptosis activation marker phosho-MLKL is reduced to almost non-detectable levels
• 9 of 10 double mutant males were able to produce pups when paired with young (10-week-old) female partners, indicating that male reproductive capacity is largely restored

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:298682 )
N
• double mutant males show significant rescue of the hormonal changes seen in single Csnk1g2em1Xidw male homozygotes at 12 months of age; all changes in testosterone, SHBG, FSH and LH are mitigated, with serum levels approximating those seen in young mice at 3 months of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory