All Phenotypes Plppr4<tm1Roni> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plppr4^tm1Roni/Plppr4^tm1Roni	involves: 129P2/OlaHsd * C57BL/6	MGI:4431240
ht2	Plppr4^tm1Roni/Plppr4⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:4431242
cx3	Plppr4^tm1Roni/Plppr4^tm1Roni Lpar2^tm1Jch/Lpar2^tm1Jch	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4431244

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:157318 )

• 50% of mice die around 3 weeks of age during status epilecpticus

nervous system

nervous system phenotype ( J:157318 )

N	• mice exhibit normal hippocampus structure, inhibitory postsynaptic currents, and synaptic molecular machinery

decreased brain weight ( J:157318 )

• P40 to P60

abnormal nervous system physiology ( J:157318 )

• hippocampus slices bathed in carbachol exhibit interictal discharges unlike wild-type slices

seizures ( J:157318 )

• at P20, some mice exhibit seizure-like movements unlike wild-type mice

• between P19 to P31, all mice exhibit hypersynchronized activity and preictal events unlike wild-type mice

• for two days after P20, 50% of mice exhibit electrographic ictal events and tonic-clonic seizures unlike wild-type mice

• mice die during status epilecpticus

• preictal events occur in one hemisphere while ictal activity occurs in both hemispheres

• some mice exhibit hypersynchronized activity without ictal events

tonic-clonic seizures ( J:157318 )

• for two days after P20, 50% of mice exhibit electrographic ictal events and tonic-clonic seizures unlike wild-type mice

abnormal excitatory postsynaptic potential ( J:157318 )

• mice exhibit hyperexcitability of evoked field excitatory postsynaptic potentials compared with similarly treated wild-type mice

abnormal miniature excitatory postsynaptic currents ( J:157318 )

• mice produce a higher miniature excitatory postsynaptic current (mEPSC) frequency compared with wild-type mice

• however, mEPSC amplitudes are normal

• LPA-treated mice exhibit a reduced increase in mEPSC frequency compared with similarly treated wild-type mice

growth/size/body

decreased body weight ( J:157318 )

• between P9 and P35

behavior/neurological

seizures ( J:157318 )

• at P20, some mice exhibit seizure-like movements unlike wild-type mice

• between P19 to P31, all mice exhibit hypersynchronized activity and preictal events unlike wild-type mice

• for two days after P20, 50% of mice exhibit electrographic ictal events and tonic-clonic seizures unlike wild-type mice

• mice die during status epilecpticus

• preictal events occur in one hemisphere while ictal activity occurs in both hemispheres

• some mice exhibit hypersynchronized activity without ictal events

tonic-clonic seizures ( J:157318 )

• for two days after P20, 50% of mice exhibit electrographic ictal events and tonic-clonic seizures unlike wild-type mice

Allelic Composition	Plppr4^tm1Roni/Plppr4⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plppr4^tm1Roni mutation (0 available); any Plppr4 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal excitatory postsynaptic potential ( J:157318 )

• mice exhibit intermediate hyperexcitability of evoked field excitatory postsynaptic potentials compared with wild-type mice and homozygotes

Allelic Composition	Plppr4^tm1Roni/Plppr4^tm1Roni Lpar2^tm1Jch/Lpar2^tm1Jch
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lpar2^tm1Jch mutation (0 available); any Lpar2 mutation (13 available)
Plppr4^tm1Roni mutation (0 available); any Plppr4 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:157318 )

N	• mice do not exhibit increased mortality around P21

nervous system

nervous system phenotype ( J:157318 )

N	• mice do not exhibit seizure activity or epileptic discharge

abnormal miniature excitatory postsynaptic currents ( J:157318 )

• CA1 pyramidal cells exhibit a reduced miniature excitatory postsynaptic current frequency compared to in wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:157318 )

N	• mice do not exhibit seizure activity or epileptic discharge

growth/size/body

growth/size/body region phenotype ( J:157318 )

N	• mice exhibit normal body weight

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