All Phenotypes Plppr4<tm1Roni> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plppr4^tm1Roni/Plppr4^tm1Roni	involves: 129P2/OlaHsd * C57BL/6	MGI:4431240
ht2	Plppr4^tm1Roni/Plppr4⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:4431242
cx3	Plppr4^tm1Roni/Plppr4^tm1Roni Lpar2^tm1Jch/Lpar2^tm1Jch	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4431244

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:157318 )

• 50% of mice die around 3 weeks of age during status epilecpticus

nervous system

nervous system phenotype ( J:157318 )

N	• mice exhibit normal hippocampus structure, inhibitory postsynaptic currents, and synaptic molecular machinery

decreased brain weight ( J:157318 )

• P40 to P60

abnormal nervous system physiology ( J:157318 )

• hippocampus slices bathed in carbachol exhibit interictal discharges unlike wild-type slices

seizures ( J:157318 )

• at P20, some mice exhibit seizure-like movements unlike wild-type mice

• between P19 to P31, all mice exhibit hypersynchronized activity and preictal events unlike wild-type mice

• for two days after P20, 50% of mice exhibit electrographic ictal events and tonic-clonic seizures unlike wild-type mice

• mice die during status epilecpticus

• preictal events occur in one hemisphere while ictal activity occurs in both hemispheres

• some mice exhibit hypersynchronized activity without ictal events

tonic-clonic seizures ( J:157318 )

• for two days after P20, 50% of mice exhibit electrographic ictal events and tonic-clonic seizures unlike wild-type mice

abnormal excitatory postsynaptic potential ( J:157318 )

• mice exhibit hyperexcitability of evoked field excitatory postsynaptic potentials compared with similarly treated wild-type mice

abnormal miniature excitatory postsynaptic currents ( J:157318 )

• mice produce a higher miniature excitatory postsynaptic current (mEPSC) frequency compared with wild-type mice

• however, mEPSC amplitudes are normal

• LPA-treated mice exhibit a reduced increase in mEPSC frequency compared with similarly treated wild-type mice

growth/size/body

decreased body weight ( J:157318 )

• between P9 and P35

behavior/neurological

seizures ( J:157318 )

• at P20, some mice exhibit seizure-like movements unlike wild-type mice

• between P19 to P31, all mice exhibit hypersynchronized activity and preictal events unlike wild-type mice

• for two days after P20, 50% of mice exhibit electrographic ictal events and tonic-clonic seizures unlike wild-type mice

• mice die during status epilecpticus

• preictal events occur in one hemisphere while ictal activity occurs in both hemispheres

• some mice exhibit hypersynchronized activity without ictal events

tonic-clonic seizures ( J:157318 )

• for two days after P20, 50% of mice exhibit electrographic ictal events and tonic-clonic seizures unlike wild-type mice

Allelic Composition	Plppr4^tm1Roni/Plppr4⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plppr4^tm1Roni mutation (0 available); any Plppr4 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal excitatory postsynaptic potential ( J:157318 )

• mice exhibit intermediate hyperexcitability of evoked field excitatory postsynaptic potentials compared with wild-type mice and homozygotes

Allelic Composition	Plppr4^tm1Roni/Plppr4^tm1Roni Lpar2^tm1Jch/Lpar2^tm1Jch
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lpar2^tm1Jch mutation (0 available); any Lpar2 mutation (13 available)
Plppr4^tm1Roni mutation (0 available); any Plppr4 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:157318 )

N	• mice do not exhibit increased mortality around P21

nervous system

nervous system phenotype ( J:157318 )

N	• mice do not exhibit seizure activity or epileptic discharge

abnormal miniature excitatory postsynaptic currents ( J:157318 )

• CA1 pyramidal cells exhibit a reduced miniature excitatory postsynaptic current frequency compared to in wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:157318 )

N	• mice do not exhibit seizure activity or epileptic discharge

growth/size/body

growth/size/body region phenotype ( J:157318 )

N	• mice exhibit normal body weight

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24