About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ephb2tm3.1Jf
targeted mutation 3.1, Jonas Frisen
MGI:4431255
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ephb2tm3.1Jf/Ephb2tm3.1Jf involves: 129S1/Sv * 129X1/SvJ MGI:5306597
ht2
 		Ephb2tm3.1Jf/Ephb2+ involves: 129S1/Sv * 129X1/SvJ MGI:5306596
cx3
 		Ephb2tm3.1Jf/Ephb2tm3.1Jf
Ephb3tm1Kln/Ephb3tm1Kln 		involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * CD-1 MGI:4431258


Genotype
MGI:5306597
hm1
Allelic
Composition		 Ephb2tm3.1Jf/Ephb2tm3.1Jf
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb2tm3.1Jf mutation (0 available); any Ephb2 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:176056 )
• most mice exhibit ventral-temporal (VT) retinal ganglion cell axon mapping defects compared with control mice




Genotype
MGI:5306596
ht2
Allelic
Composition		 Ephb2tm3.1Jf/Ephb2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb2tm3.1Jf mutation (0 available); any Ephb2 mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:176056 )
• some mice exhibit ventral-temporal (VT) retinal ganglion cell axon mapping defects compared with control mice




Genotype
MGI:4431258
cx3
Allelic
Composition		 Ephb2tm3.1Jf/Ephb2tm3.1Jf
Ephb3tm1Kln/Ephb3tm1Kln
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb2tm3.1Jf mutation (0 available); any Ephb2 mutation (68 available)
Ephb3tm1Kln mutation (1 available); any Ephb3 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:157019 )
N
• unlike in Ephb2tm2Paw Ephb3tm1Kln double mutants, Paneth cell positioning is normal
abnormal small intestinal crypt cell proliferation ( J:157019 )
• the number of mitotic cells in intestinal crypts was reduced to a similar extent as in Ephb2tm2Paw Ephb3tm1Kln double mutants

cellular
abnormal small intestinal crypt cell proliferation ( J:157019 )
• the number of mitotic cells in intestinal crypts was reduced to a similar extent as in Ephb2tm2Paw Ephb3tm1Kln double mutants




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory