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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ephb2tm4.1Jf
targeted mutation 4.1, Jonas Frisen
MGI:4431257
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Ephb2tm4.1Jf/Ephb2tm4.1Jf
Ephb3tm1Kln/Ephb3tm1Kln 		involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * CD-1 MGI:4431260
cx2
 		Ephb2tm4.1Jf/Ephb2+
Ephb3tm1Kln/Ephb3tm1Kln 		involves: 129S1/Sv * 129X1/SvJ MGI:5306602
cx3
 		Ephb2tm4.1Jf/Ephb2tm4.1Jf
Ephb3tm1Kln/Ephb3tm1Kln 		involves: 129S1/Sv * 129X1/SvJ MGI:5306603


Genotype
MGI:4431260
cx1
Allelic
Composition		 Ephb2tm4.1Jf/Ephb2tm4.1Jf
Ephb3tm1Kln/Ephb3tm1Kln
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb2tm4.1Jf mutation (0 available); any Ephb2 mutation (68 available)
Ephb3tm1Kln mutation (1 available); any Ephb3 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:157019 )
N
• unlike in Ephb2tm2Paw Ephb3tm1Kln double mutants, Paneth cell positioning is normal
abnormal digestive system physiology ( J:157019 )
• reduction in the number of mitotic cells in intestinal crypts was indistinguishable from unlike in Ephb2tm3.1Jf Ephb3tm1Kln double mutants




Genotype
MGI:5306602
cx2
Allelic
Composition		 Ephb2tm4.1Jf/Ephb2+
Ephb3tm1Kln/Ephb3tm1Kln
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb2tm4.1Jf mutation (0 available); any Ephb2 mutation (68 available)
Ephb3tm1Kln mutation (1 available); any Ephb3 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:176056 )
• some mice exhibit ventral-temporal (VT) retinal ganglion cell axon mapping defects compared with control mice




Genotype
MGI:5306603
cx3
Allelic
Composition		 Ephb2tm4.1Jf/Ephb2tm4.1Jf
Ephb3tm1Kln/Ephb3tm1Kln
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb2tm4.1Jf mutation (0 available); any Ephb2 mutation (68 available)
Ephb3tm1Kln mutation (1 available); any Ephb3 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:176056 )
• some mice exhibit ventral-temporal (VT) retinal ganglion cell axon mapping defects compared with control mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory