Phenotypes associated with this allele

• Allele Symbol: Kif21b^{tm2a(KOMP)Wtsi}
• Allele Name: targeted mutation 2a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4431403
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kif21b^tm2a(KOMP)Wtsi/Kif21b^tm2a(KOMP)Wtsi	C57BL/6N-Kif21b^tm2a(KOMP)Wtsi	MGI:6108126

Genotype
MGI:6108126

hm1

• Allelic Composition: Kif21b^{tm2a(KOMP)Wtsi}/Kif21b^{tm2a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Kif21b^{tm2a(KOMP)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:235389 )

N • preference for target quadrant in absence of the platform in Morris water maze test

impaired cued conditioning behavior ( J:235389 )

• significantly less freezing in first 30 sec. of conditioned stimulus (audio tone)

• significantly decreased freezing response to entire 8-minute conditioned stimulus (audio tone)

impaired spatial learning ( J:235389 )

• significantly longer latencies and distance to reach goal platform in Morris water maze test

nervous system

abnormal dendrite morphology ( J:235389 )

• significantly slower growth rates of microtubular cytoskeleton

• microtubules grow substantially longer

• significantly shorter distances and tighter packing between adjacent microtubules

decreased dendritic spine density ( J:235389 )

• of stubby-type and total spines on basal branches on CA1 pyramidal cells

abnormal hippocampal pyramidal neuron dendrite morphology ( J:235389 )

• significantly less branching in basal and apical dendrites on CA1 pyramidal cells

• significantly decreased density of mushroom-type spines on apical dendrites on CA1 pyramidal cells

abnormal synapse morphology ( J:235389 )

• reduced synapse numbers