Phenotypes associated with this allele

• Allele Symbol: Lancl2^{tm2a(KOMP)Wtsi}
• Allele Name: targeted mutation 2a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4431468
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lancl2^tm2a(KOMP)Wtsi/Lancl2^tm2a(KOMP)Wtsi	involves: C57BL/6N	MGI:7580960

Genotype
MGI:7580960

hm1

• Allelic Composition: Lancl2^{tm2a(KOMP)Wtsi}/Lancl2^{tm2a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased regulatory T cell number ( J:250673 )

• reduction in Tr1 (CD4+FOXP3-PD1hiIL10+) cells was observed at three weeks post H. pylori infection

decreased macrophage cell number ( J:250673 )

• significant reduction in CX3CR1+ IL10-producing macrophages at three weeks post H. pylori infection

immune system

decreased regulatory T cell number ( J:250673 )

• reduction in Tr1 (CD4+FOXP3-PD1hiIL10+) cells was observed at three weeks post H. pylori infection

decreased macrophage cell number ( J:250673 )

• significant reduction in CX3CR1+ IL10-producing macrophages at three weeks post H. pylori infection

decreased susceptibility to bacterial infection ( J:250673 )

• the gastric luminal burden of H. pylori was significantly decreased in a model of H. pylori infection