Phenotypes associated with this allele

• Allele Symbol: Sms^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4431547
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sms^tm1a(EUCOMM)Wtsi/Sms^tm1a(EUCOMM)Wtsi	B6JTyr;B6N-Sms^tm1a(EUCOMM)Wtsi/Wtsi	MGI:6263535
ot2	Sms^tm1a(EUCOMM)Wtsi/Y	B6JTyr;B6N-Sms^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5781752
ot3	Sms^tm1a(EUCOMM)Wtsi/Y	involves: C57BL/6 * C57BL/6N	MGI:5791066
ot4	Sms^tm1a(EUCOMM)Wtsi/Y	involves: C57BL/6N	MGI:5544024

Genotype
MGI:6263535

hm1

• Allelic Composition: Sms^{tm1a(EUCOMM)Wtsi}/Sms^{tm1a(EUCOMM)Wtsi}
• Genetic Background: B6JTyr;B6N-Sms^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0069_4_H07

Data Sources

IMPC Data for Sms

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

male infertility ( J:211773 )

♂

IMPC - WTSI

Genotype
MGI:5781752

ot2

• Allelic Composition: Sms^{tm1a(EUCOMM)Wtsi}/Y
• Genetic Background: B6JTyr;B6N-Sms^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0069_4_H07

Data Sources

IMPC Data for Sms

growth/size/body

decreased lean body mass ( J:175295 )

♂

IMPC - WTSI

decreased body weight ( J:175295 )

♂

IMPC - WTSI

decreased body length ( J:175295 )

♂

IMPC - WTSI

homeostasis/metabolism

increased blood urea nitrogen level ( J:175295 )

♂

IMPC - WTSI

decreased circulating glucose level ( J:175295 )

♂

IMPC - WTSI

decreased circulating potassium level ( J:175295 )

♂

IMPC - WTSI

skeleton

decreased bone mineral content ( J:175295 )

♂

IMPC - WTSI

decreased bone mineral density ( J:175295 )

♂

IMPC - WTSI

Genotype
MGI:5791066

ot3

• Allelic Composition: Sms^{tm1a(EUCOMM)Wtsi}/Y
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0069_4_H07

cellular

oligozoospermia ( J:213427 )

♂ • epididymal hypospermia

endocrine/exocrine glands

testis degeneration ( J:213427 )

♂

growth/size/body

decreased lean body mass ( J:213427 )

♂

decreased body weight ( J:213427 )

♂

decreased body length ( J:213427 )

♂

hematopoietic system

increased NK cell number ( J:213427 )

♂

increased NK T cell number ( J:213427 )

♂

immune system

increased NK cell number ( J:213427 )

♂

increased NK T cell number ( J:213427 )

♂

reproductive system

oligozoospermia ( J:213427 )

♂ • epididymal hypospermia

testis degeneration ( J:213427 )

♂

abnormal fertility/fecundity ( J:213427 )

♂

reduced male fertility ( J:213427 )

♂

skeleton

abnormal spine curvature ( J:213427 )

♂

lordosis ( J:213427 )

♂

decreased bone mineral content ( J:213427 )

♂

decreased bone mineral density ( J:213427 )

♂

Genotype
MGI:5544024

ot4

• Allelic Composition: Sms^{tm1a(EUCOMM)Wtsi}/Y
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0069_4_H07

reproductive system

male infertility ( J:200082 )

♂

growth/size/body

decreased lean body mass ( J:200082 )

♂

postnatal growth retardation ( J:200082 )

♂

muscle

muscle weakness ( J:200082 )

♂

skeleton

lordosis ( J:200082 )

♂ • lumbar

decreased bone mineral density ( J:200082 )

♂