Phenotypes associated with this allele

• Allele Symbol: Sirt2^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4431586
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sirt2^tm1a(EUCOMM)Wtsi/Sirt2^tm1a(EUCOMM)Wtsi	B6JTyr;B6N-Sirt2^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5782187
hm2	Sirt2^tm1a(EUCOMM)Wtsi/Sirt2^tm1a(EUCOMM)Wtsi	C57BL/6N-Sirt2^tm1a(EUCOMM)Wtsi/H	MGI:5782186
hm3	Sirt2^tm1a(EUCOMM)Wtsi/Sirt2^tm1a(EUCOMM)Wtsi	involves: C57BL/6 * C57BL/6N	MGI:5790624

Genotype
MGI:5782187

hm1

• Allelic Composition: Sirt2^{tm1a(EUCOMM)Wtsi}/Sirt2^{tm1a(EUCOMM)Wtsi}
• Genetic Background: B6JTyr;B6N-Sirt2^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0013_1_G11

Data Sources

IMPC Data for Sirt2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

hyperactivity ( J:165965 )

IMPC - WTSI

Genotype
MGI:5782186

hm2

• Allelic Composition: Sirt2^{tm1a(EUCOMM)Wtsi}/Sirt2^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Sirt2^{tm1a(EUCOMM)Wtsi}/H
• Cell Lines: EPD0013_1_G11

Data Sources

IMPC Data for Sirt2

homeostasis/metabolism

increased circulating cholesterol level ( J:165965 )

♀

IMPC - HAR

skeleton

increased bone mineral density ( J:165965 )

♂

IMPC - HAR

Genotype
MGI:5790624

hm3

• Allelic Composition: Sirt2^{tm1a(EUCOMM)Wtsi}/Sirt2^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0013_1_G11

normal phenotype

no abnormal phenotype detected ( J:213427 )