Phenotypes associated with this allele

• Allele Symbol: Iqcg^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4431654
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Iqcg^tm1a(EUCOMM)Wtsi/Iqcg^tm1a(EUCOMM)Wtsi	involves: C57BL/6 * C57BL/6N	MGI:6887872

Genotype
MGI:6887872

hm1

• Allelic Composition: Iqcg^{tm1a(EUCOMM)Wtsi}/Iqcg^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0105_3_A02

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:216319 )

N • female fertility is normal and cilia structures in the oviduct appear unaffected

N • adult testis weight and testis-to-body weight ratio are normal

abnormal sperm flagellum morphology ( J:216319 )

♂ • all spermatozoa show failure of proper flagellum formation

abnormal sperm axoneme morphology ( J:216319 )

♂ • sperm axoneme is disorganized and hardly any normal "9 + 2" arrangement of microtubules can be found in step 16 spermatids

short sperm flagellum ( J:216319 )

♂ • most spermatozoa exhibit an extremely short tail and are often connected by a thick mass of cytoplasm

♂ • some spermatozoa only display a short tail

abnormal sperm head morphology ( J:216319 )

♂ • epididymal sperm heads are often associated with a mass of cytoplasm where components of flagellar structures are scattered; a similar malformation in seen in step16 spermatids

abnormal sperm nucleus morphology ( J:216319 )

♂ • ~18.3% of spermatozoa exhibit nuclear shaping defects versus ~3.0% of wild-type spermatozoa

immotile sperm ( J:216319 )

♂ • spermatozoa show total immobility

abnormal spermiogenesis ( J:216319 )

♂ • although both the mitotic and meiotic phases of spermatogenesis appear normal, no visible sperm flagella are detected in the lumens of stage VII-VII seminiferous tubules in adult males

♂ • elongating spermatids show disrupted flagellum formation: the axoneme is very short and occasionally frizzled

♂ • some step 12 spermatids show malformed head shapes

♂ • however, most elongating spermatids show normal manchette structures

abnormal caput epididymis morphology ( J:216319 )

♂ • no spermatozoa are detected in the lumen of the caput epididymis

abnormal cauda epididymis morphology ( J:216319 )

♂ • cauda epididymis only contains malformed spermatozoa and degenerated cell debris

male infertility ( J:216319 )

♂ • adult males are completely infertile

♂ • however, mating behavior is normal

cellular

cellular phenotype ( J:216319 )

N • cilia structures in the trachea and oviduct appear unaffected in terms of cilia length, 9 + 2 arrangement of microtubules and motility

abnormal sperm flagellum morphology ( J:216319 )

♂ • all spermatozoa show failure of proper flagellum formation

abnormal sperm axoneme morphology ( J:216319 )

♂ • sperm axoneme is disorganized and hardly any normal "9 + 2" arrangement of microtubules can be found in step 16 spermatids

short sperm flagellum ( J:216319 )

♂ • some spermatozoa only display a short tail

♂ • most spermatozoa exhibit an extremely short tail and are often connected by a thick mass of cytoplasm

abnormal sperm head morphology ( J:216319 )

♂ • epididymal sperm heads are often associated with a mass of cytoplasm where components of flagellar structures are scattered; a similar malformation in seen in step16 spermatids

abnormal sperm nucleus morphology ( J:216319 )

♂ • ~18.3% of spermatozoa exhibit nuclear shaping defects versus ~3.0% of wild-type spermatozoa

immotile sperm ( J:216319 )

♂ • spermatozoa show total immobility

respiratory system

respiratory system phenotype ( J:216319 )

N • cilia structures in the trachea appear unaffected