Phenotypes associated with this allele

• Allele Symbol: Mcph1^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4431685
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mcph1^tm1a(EUCOMM)Wtsi/Mcph1^tm1a(EUCOMM)Wtsi	B6JTyr;B6N-Mcph1^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5781665
hm2	Mcph1^tm1a(EUCOMM)Wtsi/Mcph1^tm1a(EUCOMM)Wtsi	involves: C57BL/6 * C57BL/6N	MGI:5790968

Genotype
MGI:5781665

hm1

• Allelic Composition: Mcph1^{tm1a(EUCOMM)Wtsi}/Mcph1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: B6JTyr;B6N-Mcph1^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0080_2_A02

Data Sources

IMPC Data for Mcph1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

absent pinna reflex ( J:175295 )

IMPC - WTSI

increased thermal nociceptive threshold ( J:175295 )

IMPC - WTSI

cardiovascular system

cornea vascularization ( J:175295 )

♀

IMPC - WTSI

growth/size/body

decreased lean body mass ( J:175295 )

IMPC - WTSI

decreased body weight ( J:175295 )

IMPC - WTSI

pigmentation

abnormal eye pigmentation ( J:175295 )

♀

IMPC - WTSI

skeleton

decreased bone mineral density ( J:175295 )

♀

IMPC - WTSI

vision/eye

abnormal eye pigmentation ( J:175295 )

♀

IMPC - WTSI

abnormal cornea morphology ( J:175295 )

♀

IMPC - WTSI

cornea vascularization ( J:175295 )

♀

IMPC - WTSI

cornea opacity ( J:175295 )

♀

IMPC - WTSI

Genotype
MGI:5790968

hm2

• Allelic Composition: Mcph1^{tm1a(EUCOMM)Wtsi}/Mcph1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0080_2_A02

behavior/neurological

absent pinna reflex ( J:213427 )

growth/size/body

microcephaly ( J:213427 )

cardiovascular system

persistent hyaloid artery ( J:213427 )

cornea vascularization ( J:213427 )

cellular

chromosomal instability ( J:213427 )

hearing/vestibular/ear

abnormal auditory brainstem response ( J:213427 )

hematopoietic system

increased B cell number ( J:213427 )

immune system

increased B cell number ( J:213427 )

reproductive system

abnormal reproductive system morphology ( J:213427 )

small gonad ( J:213427 )

abnormal fertility/fecundity ( J:213427 )

skeleton

decreased bone mineral content ( J:213427 )

decreased trabecular bone volume ( J:213427 )

decreased bone trabecula number ( J:213427 )

decreased trabecular bone mass ( J:213427 )

vision/eye

persistent hyaloid artery ( J:213427 )

abnormal cornea morphology ( J:213427 )

cornea vascularization ( J:213427 )

increased cornea thickness ( J:213427 )

abnormal cornea stroma morphology ( J:213427 )

cornea opacity ( J:213427 )

abnormal eye anterior chamber morphology ( J:213427 )

abnormal lens morphology ( J:213427 )

cataract ( J:213427 )

microphthalmia ( J:213427 )

disorganized retina layers ( J:213427 )