Analysis Tools|
Allele Symbol Allele Name Allele ID |
Smyd5tm1a(EUCOMM)Wtsi targeted mutation 1a, Wellcome Trust Sanger Institute MGI:4431696 |
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| Summary |
2 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit protection from dextran sulfate sodium (DSS)-induced colitis, with mice losing less weight than controls, better-shaped stools and less rectal bleeding, less colon shortening, less extensive ulceration and erosion, less severe inflammatory cell infiltration, less thickening of mucosa, and improved epithelial barrier integrity
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• mice show a slight, but significant, increase in the number of mitochondria in intestinal epithelial cells
• however, mitochondrial perimeter and circularity in intestinal epithelial cells do not show any differences
• however, mice show no other abnormalities in the gastrointestinal tract under basal conditions
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• mice exhibit protection from dextran sulfate sodium (DSS)-induced colitis, with mice losing less weight than controls, better-shaped stools and less rectal bleeding, less colon shortening, less extensive ulceration and erosion, less severe inflammatory cell infiltration, less thickening of mucosa, and improved epithelial barrier integrity
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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