Phenotypes associated with this allele

• Allele Symbol: Slc38a10^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4431702
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc38a10^tm1a(EUCOMM)Wtsi/Slc38a10^tm1a(EUCOMM)Wtsi	B6JTyr;B6N-Slc38a10^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5781743
hm2	Slc38a10^tm1a(EUCOMM)Wtsi/Slc38a10^tm1a(EUCOMM)Wtsi	C57BL/6N-Slc38a10^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5757724
hm3	Slc38a10^tm1a(EUCOMM)Wtsi/Slc38a10^tm1a(EUCOMM)Wtsi	involves: C57BL/6 * C57BL/6N	MGI:5791064

Genotype
MGI:5781743

hm1

• Allelic Composition: Slc38a10^{tm1a(EUCOMM)Wtsi}/Slc38a10^{tm1a(EUCOMM)Wtsi}
• Genetic Background: B6JTyr;B6N-Slc38a10^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0058_1_A04

Data Sources

IMPC Data for Slc38a10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:175295 )

IMPC - WTSI

craniofacial

abnormal cranium morphology ( J:175295 )

♂

IMPC - WTSI

abnormal maxilla morphology ( J:175295 )

♂

IMPC - WTSI

growth/size/body

decreased lean body mass ( J:175295 )

IMPC - WTSI

decreased body weight ( J:175295 )

IMPC - WTSI

decreased body length ( J:175295 )

IMPC - WTSI

hematopoietic system

decreased erythrocyte cell number ( J:175295 )

IMPC - WTSI

decreased hemoglobin content ( J:175295 )

IMPC - WTSI

homeostasis/metabolism

decreased circulating calcium level ( J:175295 )

IMPC - WTSI

decreased circulating alkaline phosphatase level ( J:175295 )

IMPC - WTSI

decreased circulating total protein level ( J:175295 )

IMPC - WTSI

skeleton

abnormal cranium morphology ( J:175295 )

♂

IMPC - WTSI

abnormal maxilla morphology ( J:175295 )

♂

IMPC - WTSI

decreased bone mineral content ( J:175295 )

IMPC - WTSI

decreased bone mineral density ( J:175295 )

IMPC - WTSI

Genotype
MGI:5757724

hm2

• Allelic Composition: Slc38a10^{tm1a(EUCOMM)Wtsi}/Slc38a10^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Slc38a10^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0058_1_A04

Data Sources

IMPC Data for Slc38a10

growth/size/body

decreased body length ( J:211773 )

♂

IMPC - WTSI

homeostasis/metabolism

increased circulating iron level ( J:211773 )

♀

IMPC - WTSI

decreased circulating alkaline phosphatase level ( J:211773 )

IMPC - WTSI

skeleton

abnormal bone structure ( J:211773 )

IMPC - WTSI

Genotype
MGI:5791064

hm3

• Allelic Composition: Slc38a10^{tm1a(EUCOMM)Wtsi}/Slc38a10^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0058_1_A04

adipose tissue

decreased total body fat amount ( J:213427 )

liver/biliary system

abnormal liver physiology ( J:213427 )

• absent or minimal hepatic lipidosis

growth/size/body

decreased lean body mass ( J:213427 )

decreased body weight ( J:213427 )

decreased body length ( J:213427 )

homeostasis/metabolism

increased circulating creatinine level ( J:213427 )

decreased circulating amylase level ( J:213427 )

decreased circulating serum albumin level ( J:213427 )

increased energy expenditure ( J:213427 )

increased oxygen consumption ( J:213427 )

skeleton

decreased length of long bones ( J:213427 )

decreased bone mineral content ( J:213427 )

decreased bone mineral density ( J:213427 )

fragile skeleton ( J:213427 )