Phenotypes associated with this allele

• Allele Symbol: Lrig1^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4431776
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrig1^tm1a(EUCOMM)Wtsi/Lrig1^tm1a(EUCOMM)Wtsi	B6Brd;B6Dnk;B6N-Tyr^c-Brd Lrig1^tm1a(EUCOMM)Wtsi/Wtsi	MGI:6272832
hm2	Lrig1^tm1a(EUCOMM)Wtsi/Lrig1^tm1a(EUCOMM)Wtsi	B6Brd;B6N-Tyr^c-Brd Lrig1^tm1a(EUCOMM)Wtsi/Wtsi	MGI:6272828
hm3	Lrig1^tm1a(EUCOMM)Wtsi/Lrig1^tm1a(EUCOMM)Wtsi	B6JTyr;B6N-Lrig1^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5781657
hm4	Lrig1^tm1a(EUCOMM)Wtsi/Lrig1^tm1a(EUCOMM)Wtsi	C57BL/6N-Lrig1^tm1a(EUCOMM)Wtsi	MGI:5641700
hm5	Lrig1^tm1a(EUCOMM)Wtsi/Lrig1^tm1a(EUCOMM)Wtsi	involves: C57BL/6 * C57BL/6N	MGI:5790967

Genotype
MGI:6272832

hm1

• Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: B6Brd;B6Dnk;B6N-Tyr^c-Brd Lrig1^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0070_3_G09

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal hair cycle ( J:232539 )

♀ • premature exogen

abnormal hair shedding ( J:232539 )

♀ • at necropsy (16 weeks of age), mice fed a high-fat diet exhibit premature separation of the club hair

Genotype
MGI:6272828

hm2

• Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: B6Brd;B6N-Tyr^c-Brd Lrig1^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0070_3_G09

integument

disheveled coat ( J:232539 )

• scruffy coat

scaly skin ( J:232539 )

abnormal skin condition ( J:232539 )

Genotype
MGI:5781657

hm3

• Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: B6JTyr;B6N-Lrig1^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0070_3_G09

Data Sources

IMPC Data for Lrig1

behavior/neurological

abnormal behavior ( J:175295 )

♂

IMPC - WTSI

integument

abnormal skin condition ( J:175295 )

IMPC - WTSI

limbs/digits/tail

abnormal tail morphology ( J:175295 )

♀

IMPC - WTSI

growth/size/body

decreased body weight ( J:165965 )

IMPC - WTSI

decreased body length ( J:165965 )

♀

IMPC - WTSI

adipose tissue

decreased total body fat amount ( J:165965 )

IMPC - WTSI

Genotype
MGI:5641700

hm4

• Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Lrig1^{tm1a(EUCOMM)Wtsi}
• Cell Lines: EPD0070_3_G09

integument

distorted hair follicle pattern ( J:209956 )

abnormal epidermis stratum basale morphology ( J:209956 )

thick epidermis ( J:209956 )

• increase in thickness of tail epidermis

scaly skin ( J:209956 )

• scaly tail skin

Genotype
MGI:5790967

hm5

• Allelic Composition: Lrig1^{tm1a(EUCOMM)Wtsi}/Lrig1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0070_3_G09

adipose tissue

decreased total body fat amount ( J:213427 )

growth/size/body

decreased body weight ( J:213427 )

hearing/vestibular/ear

abnormal auditory brainstem response ( J:213427 )

homeostasis/metabolism

decreased circulating alanine transaminase level ( J:213427 )

decreased circulating alkaline phosphatase level ( J:213427 )

decreased circulating aspartate transaminase level ( J:213427 )

immune system

increased susceptibility to bacterial infection ( J:213427 )

integument

integument phenotype ( J:213427 )

N

abnormal skin adnexa morphology ( J:213427 )

• adnexal dysplasia

abnormal hair shedding ( J:213427 )

hyperkeratosis ( J:213427 )

epidermal hyperplasia ( J:213427 )

scaly skin ( J:213427 )

abnormal skin condition ( J:213427 )

skeleton

vertebral fusion ( J:213427 )

fusion of vertebral arches ( J:213427 )

decreased bone mineral density ( J:213427 )