Phenotypes associated with this allele

• Allele Symbol: Ppp5c^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4431812
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppp5c^tm1a(EUCOMM)Wtsi/Ppp5c^tm1a(EUCOMM)Wtsi	B6Dnk;B6Brd;B6N-Ppp5c^tm1a(EUCOMM)Wtsi Tyr^c-Brd/WtsiH	MGI:5781703
hm2	Ppp5c^tm1a(EUCOMM)Wtsi/Ppp5c^tm1a(EUCOMM)Wtsi	involves: C57BL/6 * C57BL/6N	MGI:5790992

Genotype
MGI:5781703

hm1

• Allelic Composition: Ppp5c^{tm1a(EUCOMM)Wtsi}/Ppp5c^{tm1a(EUCOMM)Wtsi}
• Genetic Background: B6Dnk;B6Brd;B6N-Ppp5c^{tm1a(EUCOMM)Wtsi} Tyr^c-Brd/WtsiH
• Cell Lines: EPD0114_3_G12

Data Sources

IMPC Data for Ppp5c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:175295 )

♀

IMPC - WTSI

growth/size/body

decreased body weight ( J:165965 , J:175295 )

IMPC - WTSI (J:165965)

IMPC - WTSI (J:175295)

decreased body length ( J:165965 , J:175295 )

IMPC - WTSI (J:165965)

IMPC - WTSI (J:175295)

hematopoietic system

decreased mean corpuscular hemoglobin concentration ( J:175295 )

♂

IMPC - WTSI

homeostasis/metabolism

decreased circulating glucose level ( J:175295 )

IMPC - WTSI

decreased circulating cholesterol level ( J:175295 )

IMPC - WTSI

decreased circulating HDL cholesterol level ( J:175295 )

IMPC - WTSI

decreased circulating triglyceride level ( J:175295 )

♂

IMPC - WTSI

integument

abnormal coat/hair pigmentation ( J:175295 )

IMPC - WTSI

pigmentation

abnormal coat/hair pigmentation ( J:175295 )

IMPC - WTSI

skeleton

abnormal rib morphology ( J:165965 , J:175295 )

IMPC - WTSI (J:175295)

IMPC - WTSI ♀ (J:165965)

decreased rib number ( J:165965 , J:175295 )

IMPC - WTSI (J:165965)

IMPC - WTSI (J:175295)

decreased thoracic vertebrae number ( J:165965 )

IMPC - WTSI

decreased lumbar vertebrae number ( J:165965 , J:175295 )

IMPC - WTSI (J:175295)

IMPC - WTSI ♀ (J:165965)

vertebral fusion ( J:165965 )

IMPC - WTSI

abnormal bone structure ( J:175295 )

IMPC - WTSI

Genotype
MGI:5790992

hm2

• Allelic Composition: Ppp5c^{tm1a(EUCOMM)Wtsi}/Ppp5c^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0114_3_G12

neoplasm

increased lymphoma incidence ( J:213427 )

growth/size/body

decreased body weight ( J:213427 )

decreased body length ( J:213427 )

hematopoietic system

increased T cell number ( J:213427 )

increased CD4-positive, alpha-beta T cell number ( J:213427 )

increased CD8-positive, alpha-beta T cell number ( J:213427 )

homeostasis/metabolism

decreased respiratory quotient ( J:213427 )

immune system

increased T cell number ( J:213427 )

increased CD4-positive, alpha-beta T cell number ( J:213427 )

increased CD8-positive, alpha-beta T cell number ( J:213427 )

lymphoid hyperplasia ( J:213427 )

limbs/digits/tail

caudal vertebral fusion ( J:213427 )

caudal vertebral transformation ( J:213427 )

skeleton

abnormal rib morphology ( J:213427 )

decreased rib number ( J:213427 )

truncated ribs ( J:213427 )

decreased thoracic vertebrae number ( J:213427 )

decreased lumbar vertebrae number ( J:213427 )

vertebral fusion ( J:213427 )

caudal vertebral fusion ( J:213427 )

cervical vertebral fusion ( J:213427 )

vertebral transformation ( J:213427 )

caudal vertebral transformation ( J:213427 )