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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Arpc1btm1a(EUCOMM)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4431851
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Arpc1btm1a(EUCOMM)Wtsi/Arpc1btm1a(EUCOMM)Wtsi C57BL/6N-Arpc1btm1a(EUCOMM)Wtsi/Wtsi MGI:5630865


Genotype
MGI:5630865
hm1
Allelic
Composition		 Arpc1btm1a(EUCOMM)Wtsi/Arpc1btm1a(EUCOMM)Wtsi
Genetic
Background		 C57BL/6N-Arpc1btm1a(EUCOMM)Wtsi/Wtsi
Cell Lines EPD0423_1_B04
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arpc1btm1a(EUCOMM)Wtsi mutation (3 available); any Arpc1b mutation (28 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body length ( J:211773 )
IMPC - WTSI

hematopoietic system
thrombocytosis ( J:211773 )
IMPC - WTSI

homeostasis/metabolism

immune system

integument
pigment incontinence ( J:232539 )
• at necropsy (15.9 weeks of age), mice show mild to moderate multifocal areas of dermal fibrosis with pigment laden macrophages suggesting hair follicle rupture
skin fibrosis ( J:232539 )
• mild to moderate multifocal areas of dermal fibrosis

pigmentation
pigment incontinence ( J:232539 )
• at necropsy (15.9 weeks of age), mice show mild to moderate multifocal areas of dermal fibrosis with pigment laden macrophages suggesting hair follicle rupture

skeleton
vertebral fusion ( J:211773 )
IMPC - WTSI




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory