Phenotypes associated with this allele

• Allele Symbol: Asxl1^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4431878
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Asxl1^tm1a(EUCOMM)Wtsi/Asxl1^tm1a(EUCOMM)Wtsi	involves: C57BL/6N	MGI:5544022
ht2	Asxl1^tm1a(EUCOMM)Wtsi/Asxl1^+	B6Dnk;B6Brd;B6N-Asxl1^tm1a(EUCOMM)Wtsi Tyr^c-Brd/WtsiH	MGI:5781575
ht3	Asxl1^tm1a(EUCOMM)Wtsi/Asxl1^+	C57BL/6N-Asxl1^tm1a(EUCOMM)Wtsi/Cnrm	MGI:5782028
ht4	Asxl1^tm1a(EUCOMM)Wtsi/Asxl1^+	involves: C57BL/6N	MGI:5544023

Genotype
MGI:5544022

hm1

• Allelic Composition: Asxl1^{tm1a(EUCOMM)Wtsi}/Asxl1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0080_1_D11

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality, complete penetrance ( J:200082 )

• no mice are produced from crossing heterozygous mice

Genotype
MGI:5781575

ht2

• Allelic Composition: Asxl1^{tm1a(EUCOMM)Wtsi}/Asxl1⁺
• Genetic Background: B6Dnk;B6Brd;B6N-Asxl1^{tm1a(EUCOMM)Wtsi} Tyr^c-Brd/WtsiH
• Cell Lines: EPD0080_1_D11

Data Sources

IMPC Data for Asxl1

hematopoietic system

decreased hemoglobin content ( J:175295 )

IMPC - WTSI

decreased mean corpuscular hemoglobin ( J:175295 )

IMPC - WTSI

decreased leukocyte cell number ( J:175295 )

IMPC - WTSI

homeostasis/metabolism

increased blood uric acid level ( J:175295 )

IMPC - WTSI

decreased circulating glucose level ( J:175295 )

IMPC - WTSI

immune system

decreased leukocyte cell number ( J:175295 )

IMPC - WTSI

skeleton

decreased lumbar vertebrae number ( J:175295 )

IMPC - WTSI

increased sacral vertebrae number ( J:175295 )

IMPC - WTSI

vertebral fusion ( J:175295 )

♀

IMPC - WTSI

vision/eye

abnormal cornea morphology ( J:175295 )

♂

IMPC - WTSI

cornea opacity ( J:175295 )

♂

IMPC - WTSI

Genotype
MGI:5782028

ht3

• Allelic Composition: Asxl1^{tm1a(EUCOMM)Wtsi}/Asxl1⁺
• Genetic Background: C57BL/6N-Asxl1^{tm1a(EUCOMM)Wtsi}/Cnrm
• Cell Lines: EPD0080_1_B11

Data Sources

IMPC Data for Asxl1

behavior/neurological

abnormal coping response ( J:165965 )

♀

IMPC - HMGU

hematopoietic system

increased mean corpuscular hemoglobin concentration ( J:165965 )

IMPC - HMGU

decreased B cell number ( J:165965 )

♀

IMPC - HMGU

homeostasis/metabolism

decreased circulating free fatty acids level ( J:165965 )

IMPC - HMGU

decreased circulating triglyceride level ( J:165965 )

IMPC - HMGU

increased circulating iron level ( J:165965 )

IMPC - HMGU

increased circulating alkaline phosphatase level ( J:165965 )

IMPC - HMGU

immune system

decreased B cell number ( J:165965 )

♀

IMPC - HMGU

Genotype
MGI:5544023

ht4

• Allelic Composition: Asxl1^{tm1a(EUCOMM)Wtsi}/Asxl1⁺
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0080_1_D11

vision/eye

increased opacity of vitreous body ( J:200082 )

eye opacity ( J:200082 )

• round opacities extend from the lens into the vitreous