Phenotypes associated with this allele

• Allele Symbol: Chmp4c^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4431890
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chmp4c^tm1a(EUCOMM)Wtsi/Chmp4c^tm1a(EUCOMM)Wtsi	involves: C57BL/6N	MGI:7788850

Genotype
MGI:7788850

hm1

• Allelic Composition: Chmp4c^{tm1a(EUCOMM)Wtsi}/Chmp4c^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:359000 )

N • at 8-24 weeks of age, young adult mice exhibit normal locomotion, anxiety levels, social behaviors, and learning and memory capabilities relative to controls

N • all tested behaviors -- except social recognition -- remain normal at 25-40 weeks of age

impaired social recognition ( J:359000 )

• at 25-40 weeks of age, mice show impaired social recognition in phase 2 of the three-chamber test, exhibiting a similar level of preference for stranger 1 and stranger 2, unlike control mice which show significant preference for stranger 2

nervous system

increased miniature excitatory postsynaptic current amplitude ( J:359000 )

• at 25-40 weeks of age, mice show a tendency towards higher mEPSC amplitude in hippocampal pyramidal neurons

increased miniature excitatory postsynaptic current frequency ( J:359000 )

• at 25-40 weeks of age, mice exhibit increased mEPSC frequency in hippocampal pyramidal neurons