Analysis Tools
hematopoietic system
 N |
• no significant hematologic differences or iron-deficient anemia are detected in 16-week-old females placed on a high-fat diet (HFD) for 12 weeks starting at week 4, unlike in age-matched males
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• iron-deficient anemia in HFD-fed males, as shown by a significant increase in transferrin/log10(ferritin) ratio at 16 weeks of age
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• in HFD-fed males at 16 weeks of age
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• in HFD-fed males at 16 weeks of age
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• in HFD-fed males at 16 weeks of age
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• in HFD-fed males at 16 weeks of age
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• in HFD-fed males at 16 weeks of age
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• in HFD-fed males at 16 weeks of age
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• in HFD-fed males at 16 weeks of age
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• increased platelet count, indicating reactive thrombocytosis, in HFD-fed males at 16 weeks of age
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• reduced spleen iron content in both males and females placed on a HFD for 12 weeks
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homeostasis/metabolism
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• no significant difference in plasma potassium levels in HFD-fed mice relative to wild-type controls at 16 weeks of age
• no evidence of dyslipidemia or altered glucose tolerance
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• reduced spleen iron content in both males and females placed on a HFD for 12 weeks
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• significant increase in plasma erythropoietin concentration in HFD-fed males at 16 weeks of age
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• significant reduction in plasma iron concentration in both HFD-fed males and females
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• significant increase in plasma magnesium levels in both HFD-fed males and females at 16 weeks of age
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• significant decrease in plasma ferritin concentration in both HFD-fed males and females at 16 weeks of age
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digestive/alimentary system
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• decreased number of gastric chief cells, more severe in males than in females placed on a HFD for 12 weeks
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• more severe in males than in females placed on a HFD for 12 weeks
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• gastric hyperplasia, more severe in males than in females placed on a HFD for 12 weeks
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• inflammation and neutrophil infiltration in the gastric mucosa, more severe in males than in females placed on a HFD for 12 weeks
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immune system
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• inflammation and neutrophil infiltration in the gastric mucosa, more severe in males than in females placed on a HFD for 12 weeks
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• reduced spleen iron content in both males and females placed on a HFD for 12 weeks
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neoplasm
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• gastric adenoma with architectural and nuclear atypia typical of a dysplastic adenoma in one male mouse placed on a HFD for 12 weeks
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endocrine/exocrine glands
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• decreased number of gastric chief cells, more severe in males than in females placed on a HFD for 12 weeks
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• more severe in males than in females placed on a HFD for 12 weeks
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• gastric hyperplasia, more severe in males than in females placed on a HFD for 12 weeks
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