Phenotypes associated with this allele

• Allele Symbol: Tcf7l2^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4431951
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcf7l2^tm1a(EUCOMM)Wtsi/Tcf7l2^tm1a(EUCOMM)Wtsi	C57BL/6N-Tcf7l2^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5631611
hm2	Tcf7l2^tm1a(EUCOMM)Wtsi/Tcf7l2^tm1a(EUCOMM)Wtsi	C57BL/6-Tcf7l2^tm1a(EUCOMM)Wtsi	MGI:5449731
ht3	Tcf7l2^tm1a(EUCOMM)Wtsi/Tcf7l2^+	C57BL/6N-Tcf7l2^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5706108
ht4	Tcf7l2^tm1a(EUCOMM)Wtsi/Tcf7l2^+	C57BL/6-Tcf7l2^tm1a(EUCOMM)Wtsi	MGI:5449730

Genotype
MGI:5631611

hm1

• Allelic Composition: Tcf7l2^{tm1a(EUCOMM)Wtsi}/Tcf7l2^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Tcf7l2^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0157_5_B10

Data Sources

IMPC Data for Tcf7l2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

retroesophageal right subclavian artery ( J:239583 )

DMDD

abnormal vertebral artery morphology ( J:239583 )

DMDD

abnormal vertebral artery topology ( J:239583 )

DMDD

abnormal basilar artery morphology ( J:239583 )

DMDD

dilated liver sinusoidal space ( J:239583 )

DMDD

abnormal umbilical vein topology ( J:239583 )

DMDD

symmetric azygos veins ( J:239583 )

DMDD

absent ductus venosus valve ( J:239583 )

DMDD

duplication of ductus venosus ( J:239583 )

DMDD

abnormal inferior vena cava morphology ( J:239583 )

DMDD

abnormal inferior vena cava topology ( J:239583 )

DMDD

common truncal valve ( J:239583 )

DMDD

double outlet right ventricle ( J:239583 )

DMDD

perimembraneous ventricular septal defect ( J:239583 )

DMDD

muscular ventricular septal defect ( J:239583 )

DMDD

abnormal pulmonary valve cusp morphology ( J:239583 )

DMDD

craniofacial

basisphenoid bone foramen ( J:239583 )

DMDD

abnormal nasal septum morphology ( J:239583 )

DMDD

digestive/alimentary system

abnormal cecum position ( J:239583 )

DMDD

embryo

abnormal umbilical vein topology ( J:239583 )

DMDD

abnormal Mullerian duct morphology ( J:239583 )

DMDD

abnormal Wolffian duct morphology ( J:239583 )

DMDD

endocrine/exocrine glands

abnormal neurohypophysis morphology ( J:239583 )

DMDD

growth/size/body

abnormal nasal septum morphology ( J:239583 )

DMDD

heterochrony ( J:239583 )

DMDD

limbs/digits/tail

abnormal elbow joint morphology ( J:239583 )

DMDD

liver/biliary system

dilated liver sinusoidal space ( J:239583 )

DMDD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

muscle

abnormal eye muscle morphology ( J:239583 )

DMDD

nervous system

abnormal basilar artery morphology ( J:239583 )

DMDD

abnormal forebrain morphology ( J:239583 )

DMDD

abnormal neurohypophysis morphology ( J:239583 )

DMDD

renal/urinary system

absent kidney ( J:239583 )

DMDD

abnormal ureter topology ( J:239583 )

DMDD

respiratory system

abnormal nasal septum morphology ( J:239583 )

DMDD

skeleton

basisphenoid bone foramen ( J:239583 )

DMDD

abnormal elbow joint morphology ( J:239583 )

DMDD

vertebral fusion ( J:239583 )

DMDD

fusion of vertebral arches ( J:239583 )

DMDD

vision/eye

abnormal eye muscle morphology ( J:239583 )

DMDD

Genotype
MGI:5449731

hm2

• Allelic Composition: Tcf7l2^{tm1a(EUCOMM)Wtsi}/Tcf7l2^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6-Tcf7l2^{tm1a(EUCOMM)Wtsi}
• Cell Lines: EPD0157_5_B10

mortality/aging

lethality, complete penetrance ( J:190447 )

Genotype
MGI:5706108

ht3

• Allelic Composition: Tcf7l2^{tm1a(EUCOMM)Wtsi}/Tcf7l2⁺
• Genetic Background: C57BL/6N-Tcf7l2^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0157_5_B10

Data Sources

IMPC Data for Tcf7l2

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - WTSI

growth/size/body

increased lean body mass ( J:211773 )

IMPC - WTSI

hematopoietic system

increased red blood cell distribution width ( J:211773 )

♂

IMPC - WTSI

increased mean platelet volume ( J:211773 )

♂

IMPC - WTSI

skeleton

increased bone mineral content ( J:211773 )

♂

IMPC - WTSI

increased bone mineral density ( J:211773 )

♂

IMPC - WTSI

Genotype
MGI:5449730

ht4

• Allelic Composition: Tcf7l2^{tm1a(EUCOMM)Wtsi}/Tcf7l2⁺
• Genetic Background: C57BL/6-Tcf7l2^{tm1a(EUCOMM)Wtsi}
• Cell Lines: EPD0157_5_B10

homeostasis/metabolism

abnormal glucose homeostasis ( J:190447 )

♂ • increase in basal hepatic glucose production in hyperinsulinemic-euglycemic clamp studies

♂ • despite changes in glucose levels, no abnormalities in insulin signaling or insulin levels are detected

increased circulating glucose level ( J:190447 )

♂ • under fasting and feeding conditions

impaired glucose tolerance ( J:190447 )

♂

abnormal response/metabolism to endogenous compounds ( J:190447 )

♂ • display pyruvate intolerance that is accompanied with increased hepatic expression of gluconeogenic genes

liver/biliary system

abnormal hepatocyte physiology ( J:190447 )

♂ • increase in basal hepatic glucose production in hyperinsulinemic-euglycemic clamp studies