Phenotypes associated with this allele

• Allele Symbol: Vps33b^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4431968
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vps33b^tm1a(EUCOMM)Wtsi/Vps33b^tm1a(EUCOMM)Wtsi	C57BL/6N-Vps33b^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5631670
ht2	Vps33b^tm1a(EUCOMM)Wtsi/Vps33b^+	C57BL/6N-Vps33b^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5706123

Genotype
MGI:5631670

hm1

• Allelic Composition: Vps33b^{tm1a(EUCOMM)Wtsi}/Vps33b^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Vps33b^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0339_5_E08

Data Sources

IMPC Data for Vps33b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal placenta morphology ( J:261316 )

• branching morphology defect

abnormal trophoblast layer morphology ( J:261316 )

• small or absent trophoblast compartment

• biased differentiation (diploid/polyploid trophoblast)

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

embryonic lethality during organogenesis, complete penetrance ( J:261316 )

• lethality at E9.5-E10.5

Genotype
MGI:5706123

ht2

• Allelic Composition: Vps33b^{tm1a(EUCOMM)Wtsi}/Vps33b⁺
• Genetic Background: C57BL/6N-Vps33b^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0339_5_E08

Data Sources

IMPC Data for Vps33b

homeostasis/metabolism

increased circulating HDL cholesterol level ( J:211773 )

♂

IMPC - WTSI

skeleton

abnormal thoracic cage shape ( J:211773 )

♂

IMPC - WTSI