Analysis Tools
mortality/aging
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• mice are born at the expected Mendelian ratio and viable to adulthood
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growth/size/body
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• adult mice show a roughly 50% reduction in fat mass
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• adult mice exhibit a reduction in male (-17%) and female (-19%) body weight at 22-28 weeks of age
• however, adult organs (liver, kidney and heart) are of normal morphology and size (when corrected for body weight)
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• adult mice exhibit a decrease in body length
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• mice display a significant delay in rapid postnatal growth between weeks 2 and 4, a time point that coincides with a dietary switch from milk (20% fat) to chow (4% fat); the weight difference noted after 4 weeks of age is maintained throughout adulthood
• however, mice are indistinguishable from controls at 1 week after birth
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adipose tissue
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• adult mice show a roughly 50% reduction in fat mass
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homeostasis/metabolism
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• fasted adult mice show an increased respiratory exchange ratio (RER), suggesting an impaired switch from carbohydrates to lipids for nutrient oxidation
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• adult mice show an increased respiratory exchange ratio (RER) in response to fasting
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• adult mice show a reduction in brain triacylglycerol levels
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• adult mice show a reduction in serum triacylglycerol levels
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• mice show a roughly 40% reduction in liver triacylglycerol levels at 3.5 weeks of age
• however, liver triacylglycerol levels are relatively normal at 6 weeks of age
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liver/biliary system
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• mice show a roughly 40% reduction in liver triacylglycerol levels at 3.5 weeks of age
• however, liver triacylglycerol levels are relatively normal at 6 weeks of age
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cellular
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• fasted adult mice show an increased respiratory exchange ratio (RER), suggesting an impaired switch from carbohydrates to lipids for nutrient oxidation
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behavior/neurological
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• adult mice display a small decrease in food intake over a 24-hour period; however, this difference is not significant when adjusted for body weight
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