Phenotypes associated with this allele

• Allele Symbol: Elk4^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4432021
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Elk4^tm1a(EUCOMM)Wtsi/Elk4^tm1a(EUCOMM)Wtsi	C57BL/6N-Elk4^tm1a(EUCOMM)Wtsi/H	MGI:5782069
hm2	Elk4^tm1a(EUCOMM)Wtsi/Elk4^tm1a(EUCOMM)Wtsi	Not Specified	MGI:5782070
ht3	Elk4^tm1a(EUCOMM)Wtsi/Elk4^+	C57BL/6N-Elk4^tm1a(EUCOMM)Wtsi/H	MGI:5782068

Genotype
MGI:5782069

hm1

• Allelic Composition: Elk4^{tm1a(EUCOMM)Wtsi}/Elk4^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Elk4^{tm1a(EUCOMM)Wtsi}/H
• Cell Lines: EPD0100_4_A06

Data Sources

IMPC Data for Elk4

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal tail movements ( J:165965 )

♂

IMPC - HAR

growth/size/body

decreased lean body mass ( J:165965 )

IMPC - HAR

decreased body weight ( J:165965 )

IMPC - HAR

hematopoietic system

decreased mature B cell number ( J:165965 )

♀

IMPC - HMGU

increased B cell number ( J:165965 )

IMPC - HMGU

decreased T cell number ( J:165965 )

IMPC - HMGU

decreased CD4-positive, alpha-beta T cell number ( J:165965 )

IMPC - HMGU

decreased CD8-positive, alpha-beta T cell number ( J:165965 )

IMPC - HMGU

increased T cell number ( J:165965 )

IMPC - HMGU

homeostasis/metabolism

decreased circulating cholesterol level ( J:165965 )

IMPC - HAR

decreased circulating HDL cholesterol level ( J:165965 )

IMPC - HMGU

decreased circulating triglyceride level ( J:165965 )

IMPC - HMGU

increased circulating alkaline phosphatase level ( J:165965 )

♀

IMPC - HAR

decreased circulating serum albumin level ( J:165965 )

IMPC - HAR

decreased circulating total protein level ( J:165965 )

IMPC - HAR

increased lactate dehydrogenase level ( J:165965 )

IMPC - HAR

immune system

decreased mature B cell number ( J:165965 )

♀

IMPC - HMGU

increased B cell number ( J:165965 )

IMPC - HMGU

decreased T cell number ( J:165965 )

IMPC - HMGU

decreased CD4-positive, alpha-beta T cell number ( J:165965 )

IMPC - HMGU

decreased CD8-positive, alpha-beta T cell number ( J:165965 )

IMPC - HMGU

increased T cell number ( J:165965 )

IMPC - HMGU

skeleton

abnormal bone structure ( J:165965 )

♀

IMPC - HAR

decreased bone mineral density ( J:165965 )

♀

IMPC - HAR

abnormal bone mineralization ( J:165965 )

♀

IMPC - HAR

vision/eye

abnormal cornea morphology ( J:165965 )

♂

IMPC - HAR

cornea opacity ( J:165965 )

♂

IMPC - HAR

abnormal retina morphology ( J:165965 )

♀

IMPC - HAR

Genotype
MGI:5782070

hm2

• Allelic Composition: Elk4^{tm1a(EUCOMM)Wtsi}/Elk4^{tm1a(EUCOMM)Wtsi}
• Genetic Background: Not Specified
• Cell Lines: EPD0100_4_A06

Data Sources

IMPC Data for Elk4

hematopoietic system

decreased erythrocyte cell number ( J:165965 )

IMPC - WTSI

decreased hematocrit ( J:165965 )

IMPC - WTSI

homeostasis/metabolism

decreased circulating fructosamine level ( J:165965 )

IMPC - WTSI

decreased circulating glycerol level ( J:165965 )

♀

IMPC - WTSI

decreased circulating sodium level ( J:165965 )

♂

IMPC - WTSI

decreased circulating serum albumin level ( J:165965 )

IMPC - WTSI

decreased circulating chloride level ( J:165965 )

IMPC - WTSI

Genotype
MGI:5782068

ht3

• Allelic Composition: Elk4^{tm1a(EUCOMM)Wtsi}/Elk4⁺
• Genetic Background: C57BL/6N-Elk4^{tm1a(EUCOMM)Wtsi}/H
• Cell Lines: EPD0100_4_A06

Data Sources

IMPC Data for Elk4

growth/size/body

decreased body weight ( J:165965 )

IMPC - ICS