All Phenotypes Dynlrb1<tm1a(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dynlrb1^{tm1a(EUCOMM)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4432163

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dynlrb1^{tm1a(EUCOMM)Wtsi}/Dynlrb1^{tm1a(EUCOMM)Wtsi}	C57BL/6N-Dynlrb1^{tm1a(EUCOMM)Wtsi}/Wtsi	MGI:5631080
hm2	Dynlrb1^{tm1a(EUCOMM)Wtsi}/Dynlrb1^{tm1a(EUCOMM)Wtsi}	involves: C57BL/6N	MGI:6466699
ht3	Dynlrb1^{tm1a(EUCOMM)Wtsi}/Dynlrb1⁺	C57BL/6N-Dynlrb1^{tm1a(EUCOMM)Wtsi}/Wtsi	MGI:6461227
ht4	Dynlrb1^{tm1a(EUCOMM)Wtsi}/Dynlrb1⁺	involves: C57BL/6N	MGI:6466701
cx5	Dynlrb1^{tm1a(EUCOMM)Wtsi}/Dynlrb1⁺ Tg(Thy1-YFP)16Jrs/0	involves: C57BL/6J * C57BL/6N	MGI:6466700

Allelic Composition	Dynlrb1^{tm1a(EUCOMM)Wtsi}/Dynlrb1^{tm1a(EUCOMM)Wtsi}
Genetic Background	C57BL/6N-Dynlrb1^{tm1a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0373_7_C01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dynlrb1^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Dynlrb1 mutation (13 available)

Data Sources

IMPC Data for Dynlrb1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

Allelic Composition	Dynlrb1^{tm1a(EUCOMM)Wtsi}/Dynlrb1^{tm1a(EUCOMM)Wtsi}
Genetic Background	involves: C57BL/6N
Cell Lines	EPD0373_7_C01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dynlrb1^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Dynlrb1 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:292124 )

• homozygous mutant embryos die before E9.5

Allelic Composition	Dynlrb1^{tm1a(EUCOMM)Wtsi}/Dynlrb1⁺
Genetic Background	C57BL/6N-Dynlrb1^{tm1a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0373_7_C01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dynlrb1^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Dynlrb1 mutation (13 available)

Data Sources

IMPC Data for Dynlrb1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal bone structure ( J:211773 )

IMPC - WTSI

Allelic Composition	Dynlrb1^{tm1a(EUCOMM)Wtsi}/Dynlrb1⁺
Genetic Background	involves: C57BL/6N
Cell Lines	EPD0373_7_C01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dynlrb1^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Dynlrb1 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal dorsal root ganglion morphology ( J:292124 )

• dorsal root ganglia (DRG) neurons show reduced beta-catenin nuclear accumulation after 48 h in culture

Allelic Composition	Dynlrb1^{tm1a(EUCOMM)Wtsi}/Dynlrb1⁺ Tg(Thy1-YFP)16Jrs/0
Genetic Background	involves: C57BL/6J * C57BL/6N
Cell Lines	EPD0373_7_C01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dynlrb1^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Dynlrb1 mutation (13 available)
Tg(Thy1-YFP)16Jrs mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon extension ( J:292124 )

• DRG neurons exhibit significantly reduced axon outgrowth after 48 h in culture

cellular

abnormal axon extension ( J:292124 )

• DRG neurons exhibit significantly reduced axon outgrowth after 48 h in culture

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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