All Phenotypes Dynlrb1<tm1a(EUCOMM)Wtsi> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dynlrb1^{tm1a(EUCOMM)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4432163

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dynlrb1^{tm1a(EUCOMM)Wtsi}/Dynlrb1^{tm1a(EUCOMM)Wtsi}	C57BL/6N-Dynlrb1^{tm1a(EUCOMM)Wtsi}/Wtsi	MGI:5631080
hm2	Dynlrb1^{tm1a(EUCOMM)Wtsi}/Dynlrb1^{tm1a(EUCOMM)Wtsi}	involves: C57BL/6N	MGI:6466699
ht3	Dynlrb1^{tm1a(EUCOMM)Wtsi}/Dynlrb1⁺	C57BL/6N-Dynlrb1^{tm1a(EUCOMM)Wtsi}/Wtsi	MGI:6461227
ht4	Dynlrb1^{tm1a(EUCOMM)Wtsi}/Dynlrb1⁺	involves: C57BL/6N	MGI:6466701
cx5	Dynlrb1^{tm1a(EUCOMM)Wtsi}/Dynlrb1⁺ Tg(Thy1-YFP)16Jrs/0	involves: C57BL/6J * C57BL/6N	MGI:6466700

Allelic Composition	Dynlrb1^{tm1a(EUCOMM)Wtsi}/Dynlrb1^{tm1a(EUCOMM)Wtsi}
Genetic Background	C57BL/6N-Dynlrb1^{tm1a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0373_7_C01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dynlrb1^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Dynlrb1 mutation (12 available)

Data Sources

IMPC Data for Dynlrb1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

Allelic Composition	Dynlrb1^{tm1a(EUCOMM)Wtsi}/Dynlrb1^{tm1a(EUCOMM)Wtsi}
Genetic Background	involves: C57BL/6N
Cell Lines	EPD0373_7_C01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dynlrb1^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Dynlrb1 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:292124 )

• homozygous mutant embryos die before E9.5

Allelic Composition	Dynlrb1^{tm1a(EUCOMM)Wtsi}/Dynlrb1⁺
Genetic Background	C57BL/6N-Dynlrb1^{tm1a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0373_7_C01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dynlrb1^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Dynlrb1 mutation (12 available)

Data Sources

IMPC Data for Dynlrb1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal bone structure ( J:211773 )

IMPC - WTSI

Allelic Composition	Dynlrb1^{tm1a(EUCOMM)Wtsi}/Dynlrb1⁺
Genetic Background	involves: C57BL/6N
Cell Lines	EPD0373_7_C01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dynlrb1^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Dynlrb1 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal dorsal root ganglion morphology ( J:292124 )

• dorsal root ganglia (DRG) neurons show reduced beta-catenin nuclear accumulation after 48 h in culture

Allelic Composition	Dynlrb1^{tm1a(EUCOMM)Wtsi}/Dynlrb1⁺ Tg(Thy1-YFP)16Jrs/0
Genetic Background	involves: C57BL/6J * C57BL/6N
Cell Lines	EPD0373_7_C01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dynlrb1^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Dynlrb1 mutation (12 available)
Tg(Thy1-YFP)16Jrs mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon extension ( J:292124 )

• DRG neurons exhibit significantly reduced axon outgrowth after 48 h in culture

cellular

abnormal axon extension ( J:292124 )

• DRG neurons exhibit significantly reduced axon outgrowth after 48 h in culture

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/05/2024 MGI 6.24