Phenotypes associated with this allele

• Allele Symbol: Atg16l1^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4432181
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atg16l1^tm1a(EUCOMM)Wtsi/Atg16l1^tm1a(EUCOMM)Wtsi	C57BL/6N-Atg16l1^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5883876
hm2	Atg16l1^tm1a(EUCOMM)Wtsi/Atg16l1^tm1a(EUCOMM)Wtsi	involves: C57BL/6N	MGI:5696540
ht3	Atg16l1^tm1a(EUCOMM)Wtsi/Atg16l1^+	C57BL/6N-Atg16l1^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5781576

Genotype
MGI:5883876

hm1

• Allelic Composition: Atg16l1^{tm1a(EUCOMM)Wtsi}/Atg16l1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Atg16l1^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0102_2_A02

Data Sources

IMPC Data for Atg16l1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

absent segment of posterior cerebral artery ( J:239583 )

DMDD

abnormal vitelline vein topology ( J:239583 )

DMDD

absent ductus venosus valve ( J:239583 )

DMDD

abnormal hepatic vein morphology ( J:239583 )

DMDD

overriding aortic valve ( J:239583 )

DMDD

abnormal inferior vena cava valve morphology ( J:239583 )

DMDD

perimembraneous ventricular septal defect ( J:239583 )

DMDD

embryo

abnormal vitelline vein topology ( J:239583 )

DMDD

endocrine/exocrine glands

abnormal thymus topology ( J:239583 )

DMDD

growth/size/body

thoracoschisis ( J:239583 )

DMDD

hematopoietic system

abnormal thymus topology ( J:239583 )

DMDD

homeostasis/metabolism

subcutaneous edema ( J:239583 )

DMDD

immune system

abnormal thymus topology ( J:239583 )

DMDD

absent connection between subcutaneous lymph vessels and lymph sac ( J:239583 )

DMDD

blood in lymph vessels ( J:239583 )

DMDD

integument

subcutaneous edema ( J:239583 )

DMDD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

muscle

abnormal eye muscle morphology ( J:239583 )

DMDD

nervous system

absent segment of posterior cerebral artery ( J:239583 )

DMDD

abnormal hypoglossal nerve topology ( J:239583 )

DMDD

absent hypoglossal nerve ( J:239583 )

DMDD

abnormal intrathoracic topology of vagus nerve ( J:239583 )

DMDD

vision/eye

abnormal eye muscle morphology ( J:239583 )

DMDD

Genotype
MGI:5696540

hm2

• Allelic Composition: Atg16l1^{tm1a(EUCOMM)Wtsi}/Atg16l1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N

mortality/aging

prenatal lethality ( J:221019 )

• no viable homozygotes are found after birth

Genotype
MGI:5781576

ht3

• Allelic Composition: Atg16l1^{tm1a(EUCOMM)Wtsi}/Atg16l1⁺
• Genetic Background: C57BL/6N-Atg16l1^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0102_2_A02

Data Sources

IMPC Data for Atg16l1

hematopoietic system

increased mean corpuscular hemoglobin ( J:175295 )

♂

IMPC - WTSI

homeostasis/metabolism

increased circulating serum albumin level ( J:175295 )

IMPC - WTSI