Phenotypes associated with this allele

• Allele Symbol: Tcf4^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4432303
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcf4^tm1a(EUCOMM)Wtsi/Tcf4^tm1a(EUCOMM)Wtsi	C57BL/6N-Tcf4^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5631609
ht2	Tcf4^tm1a(EUCOMM)Wtsi/Tcf4^+	C57BL/6N-Tcf4^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5706107
ht3	Tcf4^tm1a(EUCOMM)Wtsi/Tcf4^+	involves: C57BL/6N	MGI:6479897

Genotype
MGI:5631609

hm1

• Allelic Composition: Tcf4^{tm1a(EUCOMM)Wtsi}/Tcf4^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Tcf4^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0103_3_A07

Data Sources

IMPC Data for Tcf4

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - WTSI

Genotype
MGI:5706107

ht2

• Allelic Composition: Tcf4^{tm1a(EUCOMM)Wtsi}/Tcf4⁺
• Genetic Background: C57BL/6N-Tcf4^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0103_3_A07

Data Sources

IMPC Data for Tcf4

vision/eye

abnormal retina morphology ( J:211773 )

♀

IMPC - WTSI

Genotype
MGI:6479897

ht3

• Allelic Composition: Tcf4^{tm1a(EUCOMM)Wtsi}/Tcf4⁺
• Genetic Background: involves: C57BL/6N

nervous system

abnormal corpus callosum morphology ( J:265025 )

• mice show agenesis of the splenium of the corpus callosum

abnormal dentate gyrus morphology ( J:265025 )

• dentate gyrus volume is decreased

decreased hippocampus volume ( J:265025 )

• reduction in hippocampal volume

thin cerebral cortex ( J:265025 )

• cortical thickness is reduced in all analyzed areas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Pitt-Hopkins syndrome		DOID:0060488	OMIM:610954	J:265025