Phenotypes associated with this allele

• Allele Symbol: Sesn3^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4432370
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sesn3^tm1a(EUCOMM)Wtsi/Sesn3^tm1a(EUCOMM)Wtsi	C57BL/6N-Sesn3^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5781735
cx2	Sesn2^Gt(RRJ141)Byg/Sesn2^Gt(RRJ141)Byg Sesn3^tm1a(EUCOMM)Wtsi/Sesn3^tm1a(EUCOMM)Wtsi	involves: 129P2/OlaHsd * C57BL/6N	MGI:5444498

Genotype
MGI:5781735

hm1

• Allelic Composition: Sesn3^{tm1a(EUCOMM)Wtsi}/Sesn3^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Sesn3^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0051_5_C06

Data Sources

IMPC Data for Sesn3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating sodium level ( J:175295 )

IMPC - WTSI

increased circulating chloride level ( J:175295 )

IMPC - WTSI

Genotype
MGI:5444498

cx2

• Allelic Composition: Sesn2^{Gt(RRJ141)Byg}/Sesn2^{Gt(RRJ141)Byg}; Sesn3^{tm1a(EUCOMM)Wtsi}/Sesn3^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

homeostasis/metabolism

impaired glucose tolerance ( J:189021 )

• spontaneous in mice fed a low fat diet

insulin resistance ( J:189021 )

• spontaneous in mice fed a low fat diet

liver/biliary system

liver/biliary system phenotype ( J:189021 )

N • mice do not develop hepatosteatosis

growth/size/body

growth/size/body region phenotype ( J:189021 )

N • mice exhibit normal weight