Phenotypes associated with this allele

• Allele Symbol: Nfkbid^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4432464
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nfkbid^tm1a(EUCOMM)Wtsi/Nfkbid^tm1a(EUCOMM)Wtsi	involves: C57BL/6N	MGI:5429175
ht2	Nfkbid^tm1a(EUCOMM)Wtsi/Nfkbid^+	C57BL/6N-Nfkbid^tm1a(EUCOMM)Wtsi/Cnrm	MGI:5782144

Genotype
MGI:5429175

hm1

• Allelic Composition: Nfkbid^{tm1a(EUCOMM)Wtsi}/Nfkbid^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice

decreased IgG level ( J:185495 )

• response in response to recombinant Semliki Forest virus (SFV) encoded antigen

decreased IgM level ( J:185495 )

• following NP-Ficoll immunization

hematopoietic system

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice

decreased IgG level ( J:185495 )

• response in response to recombinant Semliki Forest virus (SFV) encoded antigen

decreased IgM level ( J:185495 )

• following NP-Ficoll immunization

Genotype
MGI:5782144

ht2

• Allelic Composition: Nfkbid^{tm1a(EUCOMM)Wtsi}/Nfkbid⁺
• Genetic Background: C57BL/6N-Nfkbid^{tm1a(EUCOMM)Wtsi}/Cnrm
• Cell Lines: EPD0100_4_A03

Data Sources

IMPC Data for Nfkbid

behavior/neurological

abnormal behavior ( J:165965 )

IMPC - HMGU

hematopoietic system

decreased B cell number ( J:165965 )

IMPC - HMGU

homeostasis/metabolism

decreased circulating free fatty acids level ( J:165965 )

♂

IMPC - HMGU

decreased circulating triglyceride level ( J:165965 )

♂

IMPC - HMGU

immune system

decreased B cell number ( J:165965 )

IMPC - HMGU