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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Prmt1tm1a(EUCOMM)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4432476
Summary 3 genotypes


Genotype
MGI:6263237
hm1
Allelic
Composition
Prmt1tm1a(EUCOMM)Wtsi/Prmt1tm1a(EUCOMM)Wtsi
Genetic
Background
B6JTyr;B6N-Prmt1tm1a(EUCOMM)Wtsi/Wtsi
Cell Lines EPD0070_1_B01
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prmt1tm1a(EUCOMM)Wtsi mutation (3 available); any Prmt1 mutation (35 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5781707
ht2
Allelic
Composition
Prmt1tm1a(EUCOMM)Wtsi/Prmt1+
Genetic
Background
B6JTyr;B6N-Prmt1tm1a(EUCOMM)Wtsi/Wtsi
Cell Lines EPD0070_1_B01
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prmt1tm1a(EUCOMM)Wtsi mutation (3 available); any Prmt1 mutation (35 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism




Genotype
MGI:7486120
cn3
Allelic
Composition
Prmt1tm1a(EUCOMM)Wtsi/Prmt1tm1a(EUCOMM)Wtsi
Rb1tm3Tyj/Rb1tm3Tyj
Trp53tm1Brn/Trp53tm1Brn
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prmt1tm1a(EUCOMM)Wtsi mutation (3 available); any Prmt1 mutation (35 available)
Rb1tm3Tyj mutation (10 available); any Rb1 mutation (111 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (2 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median tumor-free survival is significantly increased relative to mutant mice that are either homozygotes for the wild-type Prmt1 allele or heterozygotes with one wild-type and one floxed Prmt1 allele

neoplasm
• microPET/CT imaging suggested a reduction in the presence of osteosarcomas at 100 days of age
• osteosarcoma tumors retain residual PRMT1 protein expression and a nonexcised Prmt1 allele
• osteosarcoma initiation is delayed relative to mutant mice that are either homozygotes for the wild-type Prmt1 allele or heterozygotes with one wild-type and one floxed Prmt1 allele

skeleton
• microPET/CT imaging suggested a reduction in the presence of osteosarcomas at 100 days of age
• osteosarcoma tumors retain residual PRMT1 protein expression and a nonexcised Prmt1 allele





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory