Analysis Tools|
Allele Symbol Allele Name Allele ID |
Prmt1tm1a(EUCOMM)Wtsi targeted mutation 1a, Wellcome Trust Sanger Institute MGI:4432476 |
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| Summary |
3 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• median tumor-free survival is significantly increased relative to mutant mice that are either homozygotes for the wild-type Prmt1 allele or heterozygotes with one wild-type and one floxed Prmt1 allele
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• microPET/CT imaging suggested a reduction in the presence of osteosarcomas at 100 days of age
• osteosarcoma tumors retain residual PRMT1 protein expression and a nonexcised Prmt1 allele
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• osteosarcoma initiation is delayed relative to mutant mice that are either homozygotes for the wild-type Prmt1 allele or heterozygotes with one wild-type and one floxed Prmt1 allele
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• microPET/CT imaging suggested a reduction in the presence of osteosarcomas at 100 days of age
• osteosarcoma tumors retain residual PRMT1 protein expression and a nonexcised Prmt1 allele
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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