About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Prmt1tm1a(EUCOMM)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4432476
Summary 3 genotypes


Genotype
MGI:6263237
hm1
Allelic
Composition
Prmt1tm1a(EUCOMM)Wtsi/Prmt1tm1a(EUCOMM)Wtsi
Genetic
Background
B6JTyr;B6N-Prmt1tm1a(EUCOMM)Wtsi/Wtsi
Cell Lines EPD0070_1_B01
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prmt1tm1a(EUCOMM)Wtsi mutation (3 available); any Prmt1 mutation (35 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5781707
ht2
Allelic
Composition
Prmt1tm1a(EUCOMM)Wtsi/Prmt1+
Genetic
Background
B6JTyr;B6N-Prmt1tm1a(EUCOMM)Wtsi/Wtsi
Cell Lines EPD0070_1_B01
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prmt1tm1a(EUCOMM)Wtsi mutation (3 available); any Prmt1 mutation (35 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism




Genotype
MGI:7486120
cn3
Allelic
Composition
Prmt1tm1a(EUCOMM)Wtsi/Prmt1tm1a(EUCOMM)Wtsi
Rb1tm3Tyj/Rb1tm3Tyj
Trp53tm1Brn/Trp53tm1Brn
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prmt1tm1a(EUCOMM)Wtsi mutation (3 available); any Prmt1 mutation (35 available)
Rb1tm3Tyj mutation (10 available); any Rb1 mutation (111 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (2 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (239 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median tumor-free survival is significantly increased relative to mutant mice that are either homozygotes for the wild-type Prmt1 allele or heterozygotes with one wild-type and one floxed Prmt1 allele

neoplasm
• microPET/CT imaging suggested a reduction in the presence of osteosarcomas at 100 days of age
• osteosarcoma tumors retain residual PRMT1 protein expression and a nonexcised Prmt1 allele
• osteosarcoma initiation is delayed relative to mutant mice that are either homozygotes for the wild-type Prmt1 allele or heterozygotes with one wild-type and one floxed Prmt1 allele

skeleton
• microPET/CT imaging suggested a reduction in the presence of osteosarcomas at 100 days of age
• osteosarcoma tumors retain residual PRMT1 protein expression and a nonexcised Prmt1 allele





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory