Phenotypes associated with this allele

• Allele Symbol: Mecr^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4432643
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mecr^tm1a(EUCOMM)Wtsi/Mecr^tm1a(EUCOMM)Wtsi	involves: C57BL/6Brd * C57BL/6Dnk * C57BL/6JOlaHsd * C57BL/6N	MGI:6390997

Genotype
MGI:6390997

hm1

• Allelic Composition: Mecr^{tm1a(EUCOMM)Wtsi}/Mecr^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6Brd * C57BL/6Dnk * C57BL/6JOlaHsd * C57BL/6N
• Cell Lines: EPD0039_5_G01

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:242847 )

• time of embryonic lethality is variable, with homozygous mutant mice dying between E9.5 and E15.5, as determined by visible heart beats or pulsing blood in umbilical vessel and necrotic signs

• few live embryos can be recovered until E14.5, but no embryos are found alive after E15.5

• no mouse embryonic fibroblasts could be established

embryo

abnormal embryo development ( J:242847 )

• embryos are adherent to yolk sac membranes at E8.5, whereas wild-type embryos are easy to separate from membranes

decreased embryo size ( J:242847 )

• embryos are smaller in size by E8.5

abnormal visceral yolk sac morphology ( J:242847 )

• yolk sac membranes are opaque, unlike the translucent clear membranes seen in wild-type embryos

growth/size/body

decreased embryo size ( J:242847 )

• embryos are smaller in size by E8.5

cardiovascular system

hemorrhage ( J:242847 )

• long-surviving embryos found alive at E14.5 show multiple hemorrhages

integument

pallor ( J:242847 )

• long-surviving embryos found alive at E14.5 appear pale