Analysis Tools
mortality/aging
|
• though present in Mendelian ratios at birth, fewer than expected mice are present at weaning with fewer than expected male mice compared with female mice
• however, mice that survive to weaning have normal life spans
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growth/size/body
|
• 50% less by 3 weeks of age in both female and male mice
• 20% less by 5 weeks of age with weight remains stable throughout young adult life
• 50% of normal at 1 year of age due to age related weight loss
|
|
• from birth and exacerbated in mice that survive beyond weaning
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cellular
| N |
• mouse embryonic fibroblasts exhibit normal chromatin sensitivity
|
homeostasis/metabolism
| N |
• newborn serum parameters are normal
|
