Phenotypes associated with this allele

• Allele Symbol: Usp42^{tm2a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 2a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4432706
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp42^tm2a(EUCOMM)Wtsi/Usp42^tm2a(EUCOMM)Wtsi	B6JTyr;B6N-Usp42^tm2a(EUCOMM)Wtsi/Wtsi	MGI:5781791
hm2	Usp42^tm2a(EUCOMM)Wtsi/Usp42^tm2a(EUCOMM)Wtsi	involves: C57BL/6 * C57BL/6N	MGI:5791072

Genotype
MGI:5781791

hm1

• Allelic Composition: Usp42^{tm2a(EUCOMM)Wtsi}/Usp42^{tm2a(EUCOMM)Wtsi}
• Genetic Background: B6JTyr;B6N-Usp42^{tm2a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0130_1_D07

Data Sources

IMPC Data for Usp42

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:175295 )

IMPC - WTSI

hyperactivity ( J:175295 )

IMPC - WTSI

growth/size/body

decreased lean body mass ( J:175295 )

IMPC - WTSI

decreased body weight ( J:175295 )

IMPC - WTSI

decreased body length ( J:175295 )

IMPC - WTSI

hematopoietic system

thrombocytopenia ( J:175295 )

♂

IMPC - WTSI

reproductive system

male infertility ( J:211773 )

♂

IMPC - WTSI

skeleton

decreased lumbar vertebrae number ( J:175295 )

♀

IMPC - WTSI

increased sacral vertebrae number ( J:175295 )

♀

IMPC - WTSI

Genotype
MGI:5791072

hm2

• Allelic Composition: Usp42^{tm2a(EUCOMM)Wtsi}/Usp42^{tm2a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0130_1_D07

behavior/neurological

abnormal behavior ( J:213427 )

hyperactivity ( J:213427 )

cellular

oligozoospermia ( J:213427 )

• epididymal hypospermia

endocrine/exocrine glands

testis degeneration ( J:213427 )

hematopoietic system

increased T cell number ( J:213427 )

increased CD4-positive, alpha-beta T cell number ( J:213427 )

immune system

increased T cell number ( J:213427 )

increased CD4-positive, alpha-beta T cell number ( J:213427 )

reproductive system

oligozoospermia ( J:213427 )

• epididymal hypospermia

testis degeneration ( J:213427 )

abnormal fertility/fecundity ( J:213427 )

vision/eye

abnormal lens morphology ( J:213427 )

cataract ( J:213427 )