Phenotypes associated with this allele

• Allele Symbol: Cnnm4^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4432730
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cnnm4^tm1a(EUCOMM)Wtsi/Cnnm4^tm1a(EUCOMM)Wtsi	involves: C57BL/6J * C57BL/6N	MGI:5638375

Genotype
MGI:5638375

hm1

• Allelic Composition: Cnnm4^{tm1a(EUCOMM)Wtsi}/Cnnm4^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: EPD0426_1_C08

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal tooth morphology ( J:207520 )

• all mice show abnormal teeth

abnormal tooth color ( J:207520 )

• all mice show abnormal teeth with chalky-white discoloration as early as 3 weeks of age

abnormal enamel morphology ( J:207520 )

• enamel rods are immature and the inter-rod area is increased, however enamel thickness is normal

• levels of calcium and phosphorus are decreased in tooth enamel, indicating hypomineralization

• mature enamel shows increased magnesium levels

abnormal enamel mineralization ( J:207520 )

• hypomineralization of tooth enamel

homeostasis/metabolism

decreased circulating magnesium level ( J:207520 )

• mice on a normal diet exhibit an approximate 18% decrease in serum magnesium levels compared to wild-type mice

• however, levels of sodium, potassium and calcium in the serum are normal

decreased urine magnesium level ( J:207520 )

• mice fed a normal diet exhibit an approximate 71% reduction in magnesium levels in the urine

craniofacial

abnormal tooth morphology ( J:207520 )

• all mice show abnormal teeth

abnormal tooth color ( J:207520 )

• all mice show abnormal teeth with chalky-white discoloration as early as 3 weeks of age

abnormal enamel morphology ( J:207520 )

• enamel rods are immature and the inter-rod area is increased, however enamel thickness is normal

• levels of calcium and phosphorus are decreased in tooth enamel, indicating hypomineralization

• mature enamel shows increased magnesium levels

abnormal enamel mineralization ( J:207520 )

• hypomineralization of tooth enamel

digestive/alimentary system

abnormal feces composition ( J:207520 )

• mice show a 22% increase in magnesium content in feces, indicating increased excretion of magnesium, without a difference in the amount of food ingested, suggesting malabsorption of magnesium in intestine

growth/size/body

abnormal tooth morphology ( J:207520 )

• all mice show abnormal teeth

abnormal tooth color ( J:207520 )

• all mice show abnormal teeth with chalky-white discoloration as early as 3 weeks of age

abnormal enamel morphology ( J:207520 )

• enamel rods are immature and the inter-rod area is increased, however enamel thickness is normal

• levels of calcium and phosphorus are decreased in tooth enamel, indicating hypomineralization

• mature enamel shows increased magnesium levels

abnormal enamel mineralization ( J:207520 )

• hypomineralization of tooth enamel

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:207520 )

• mice fed a magnesium-free diet exhibit increased mortality compared to wild-type mice on this diet

renal/urinary system

decreased urine magnesium level ( J:207520 )

• mice fed a normal diet exhibit an approximate 71% reduction in magnesium levels in the urine

vision/eye

vision/eye phenotype ( J:207520 )

N • mice exhibit normal retinas and do not show retinal degeneration or retinal dysfunction