Phenotypes associated with this allele

• Allele Symbol: Ift25^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4432759
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ift25^tm1a(EUCOMM)Wtsi/Ift25^tm1a(EUCOMM)Wtsi	B6JTyr;B6N-Ift25^tm1a(EUCOMM)Wtsi/Wtsi	MGI:6262654
hm2	Ift25^tm1a(EUCOMM)Wtsi/Ift25^tm1a(EUCOMM)Wtsi	involves: C57BL/6J * C57BL/6N	MGI:5426876
ht3	Ift25^tm1a(EUCOMM)Wtsi/Ift25^+	B6JTyr;B6N-Ift25^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5781641

Genotype
MGI:6262654

hm1

• Allelic Composition: Ift25^{tm1a(EUCOMM)Wtsi}/Ift25^{tm1a(EUCOMM)Wtsi}
• Genetic Background: B6JTyr;B6N-Ift25^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0039_5_B05

Data Sources

IMPC Data for Ift25

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

Genotype
MGI:5426876

hm2

• Allelic Composition: Ift25^{tm1a(EUCOMM)Wtsi}/Ift25^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: EPD0039_5_G06

mortality/aging

neonatal lethality, complete penetrance ( J:184749 )

cardiovascular system

abnormal atrioventricular cushion morphology ( J:184749 )

• have a single orifice with common AV valves

double outlet right ventricle ( J:184749 )

overriding aortic valve ( J:184749 )

atrioventricular septal defect ( J:184749 )

• have a single orifice with common AV valves

unbalanced complete common atrioventricular canal ( J:184749 )

• some mice display an unbalanced AVSD

ventricular septal defect ( J:184749 )

abnormal heart size ( J:184749 )

• heart size is not reduced in proportion to body size

homeostasis/metabolism

cyanosis ( J:184749 )

• at birth

craniofacial

micrognathia ( J:184749 )

cleft palate ( J:184749 )

nervous system

abnormal neural tube morphology ( J:184749 )

• patterning defects are seen at E9.5 but appear to be largely corrected by E10.5

growth/size/body

cleft palate ( J:184749 )

decreased birth body size ( J:184749 )

omphalocele ( J:184749 )

• frequently seen (23 of 29)

fetal growth retardation ( J:184749 )

• slight growth restriction at E18

left pulmonary isomerism ( J:184749 )

• in 2 of 6

skeleton

micrognathia ( J:184749 )

abnormal sternebra morphology ( J:184749 )

• mal alignment of the sternal vertebrae

small thoracic cage ( J:184749 )

• in many cases the rib cage is small and impinges on the lungs

• decrease in size is proportional to decrease in crown to rump length

limbs/digits/tail

polydactyly ( J:184749 )

• in 6 of 29

preaxial polydactyly ( J:184749 )

respiratory system

left pulmonary isomerism ( J:184749 )

• in 2 of 6

digestive/alimentary system

cleft palate ( J:184749 )

embryo

abnormal neural tube morphology ( J:184749 )

• patterning defects are seen at E9.5 but appear to be largely corrected by E10.5

Genotype
MGI:5781641

ht3

• Allelic Composition: Ift25^{tm1a(EUCOMM)Wtsi}/Ift25⁺
• Genetic Background: B6JTyr;B6N-Ift25^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0039_5_B05

Data Sources

IMPC Data for Ift25

behavior/neurological

abnormal behavior ( J:175295 )

♀

IMPC - WTSI

homeostasis/metabolism

increased circulating free fatty acids level ( J:175295 )

♀

IMPC - WTSI

increased circulating glycerol level ( J:175295 )

♀

IMPC - WTSI