Phenotypes associated with this allele

• Allele Symbol: Nudt2^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4432760
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nudt2^tm1a(EUCOMM)Wtsi/Nudt2^tm1a(EUCOMM)Wtsi	C57BL/6-Nudt2^tm1a(EUCOMM)Wtsi	MGI:7619716

Genotype
MGI:7619716

hm1

• Allelic Composition: Nudt2^{tm1a(EUCOMM)Wtsi}/Nudt2^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6-Nudt2^{tm1a(EUCOMM)Wtsi}
• Cell Lines: EPD0146_2_H06

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal fibroblast physiology ( J:315167 )

• mouse embryonic fibroblasts (MEFs) from mice infected with VSV show up to a 100-fold increase in VSV release into the supernatant and higher accumulation of vesicular stomatitis virus nucleocapsid protein (VSV-N) RNA indicating increased virus growth

• however, infectious particles and viral RNA accumulation of herpes simplex virus 1 (HSV-1) and Semliki forest virus (SFV) are comparable to wild-type MEFs

hematopoietic system

abnormal bone marrow cell physiology ( J:315167 )

• bone marrow cells infected with vesicular stomatitis virus (VSV) show a 10- to 30-fold increase in infectious virus particles

immune system

immune system phenotype ( J:315167 )

N • mice intranasally infected with VSV using an intranasal infection regime causing encephalitis show no differences in survival rates compared to wild-type infected mice and viral RNA load in the cerebellum is not different

N • mice do not show spontaneous upregulation of mRNA encoding for classing antiviral proteins, inflammatory cytokines, or U1 snRNA in heart, liver, lung, or spleen, indicating no general perturbation of the cellular innate immune response