Phenotypes associated with this allele

• Allele Symbol: Trmt10a^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4432852
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trmt10a^tm1a(EUCOMM)Wtsi/Trmt10a^tm1a(EUCOMM)Wtsi	C57BL/6N-Trmt10a^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5781786
hm2	Trmt10a^tm1a(EUCOMM)Wtsi/Trmt10a^tm1a(EUCOMM)Wtsi	involves: C57BL/6N	MGI:5544021

Genotype
MGI:5781786

hm1

• Allelic Composition: Trmt10a^{tm1a(EUCOMM)Wtsi}/Trmt10a^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Trmt10a^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0140_1_C09

Data Sources

IMPC Data for Trmt10a

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:175295 )

IMPC - WTSI

homeostasis/metabolism

decreased circulating cholesterol level ( J:175295 )

IMPC - WTSI

decreased circulating HDL cholesterol level ( J:175295 )

IMPC - WTSI

decreased circulating LDL cholesterol level ( J:175295 )

IMPC - WTSI

increased circulating free fatty acids level ( J:175295 )

IMPC - WTSI

increased circulating glycerol level ( J:175295 )

IMPC - WTSI

decreased circulating alanine transaminase level ( J:175295 )

IMPC - WTSI

decreased circulating aspartate transaminase level ( J:175295 )

IMPC - WTSI

skeleton

increased sacral vertebrae number ( J:175295 )

♀

IMPC - WTSI

vision/eye

abnormal lens morphology ( J:175295 )

♀

IMPC - WTSI

cataract ( J:175295 )

♀

IMPC - WTSI

Genotype
MGI:5544021

hm2

• Allelic Composition: Trmt10a^{tm1a(EUCOMM)Wtsi}/Trmt10a^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0140_1_C09

homeostasis/metabolism

increased circulating magnesium level ( J:200082 )

♂ • in male mice