Phenotypes associated with this allele

• Allele Symbol: Plekhm2^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4432896
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plekhm2^tm1a(EUCOMM)Wtsi/Plekhm2^tm1a(EUCOMM)Wtsi	B6JTyr;B6N-Plekhm2^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5781700
hm2	Plekhm2^tm1a(EUCOMM)Wtsi/Plekhm2^tm1a(EUCOMM)Wtsi	involves: C57BL/6J * C57BL/6N	MGI:5805422

Genotype
MGI:5781700

hm1

• Allelic Composition: Plekhm2^{tm1a(EUCOMM)Wtsi}/Plekhm2^{tm1a(EUCOMM)Wtsi}
• Genetic Background: B6JTyr;B6N-Plekhm2^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0089_2_F03

Data Sources

IMPC Data for Plekhm2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:165965 , J:175295 )

IMPC - WTSI (J:165965)

IMPC - WTSI (J:175295)

immune system

increased leukocyte cell number ( J:165965 )

♀

IMPC - WTSI

hematopoietic system

decreased hematocrit ( J:165965 )

IMPC - WTSI

decreased hemoglobin content ( J:165965 )

IMPC - WTSI

increased leukocyte cell number ( J:165965 )

♀

IMPC - WTSI

Genotype
MGI:5805422

hm2

• Allelic Composition: Plekhm2^{tm1a(EUCOMM)Wtsi}/Plekhm2^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:233985 )

• Salmonella-infected mice succumb later than wild-type mice (9 days compared to 7.5 days)

• delta sifA-Salmonella-infected mice succumb later than wild-type mice (9 days compared to 7 days)

immune system

increased leukocyte cell number ( J:233985 )

• slightly

decreased susceptibility to bacterial infection ( J:233985 )

• Salmonella-infected mice exhibit reduced bacterial count in the small intestine due to reduced bacterial replication in macrophages compared with wild-type mice

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:233985 )

• Salmonella-infected mice succumb later than wild-type mice (9 days compared to 7.5 days)

• delta sifA-Salmonella-infected mice succumb later than wild-type mice (9 days compared to 7 days)

hematopoietic system

increased leukocyte cell number ( J:233985 )

• slightly

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:233985 )