All Phenotypes Ccnyl1<tm1a(EUCOMM)Wtsi> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccnyl1^{tm1a(EUCOMM)Wtsi}/Ccnyl1^{tm1a(EUCOMM)Wtsi}	involves: C57BL/6N	MGI:5688385
cx2	Ccny^tm1.1Smoc/Ccny⁺ Ccnyl1^{tm1a(EUCOMM)Wtsi}/Ccnyl1^{tm1a(EUCOMM)Wtsi}	involves: C57BL/6N	MGI:5688389
cx3	Ccny^tm1.1Smoc/Ccny^tm1.1Smoc Ccnyl1^{tm1a(EUCOMM)Wtsi}/Ccnyl1^{tm1a(EUCOMM)Wtsi}	involves: C57BL/6N	MGI:5688387
cx4	Ccny^tm1.1Smoc/Ccny^tm1.1Smoc Ccnyl1^{tm1a(EUCOMM)Wtsi}/Ccnyl1⁺	involves: C57BL/6N	MGI:5688388

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:224586 )

N	• female mice exhibit normal fertility

teratozoospermia ( J:224586 )

• many sperm exhibit heads that are bent and wrapped around the next

• spermatozoa from the cauda epididymis lack cytoplasmic droplets

• however, capacitation ability is intact

abnormal sperm annulus morphology ( J:224586 )

• thinning

• with a sharp bend in half of spermatozoa

absent sperm mitochondrial sheath ( J:224586 )

• at the thinned annulus region

decreased sperm progressive motility ( J:224586 )

• progressive spermatozoa exhibit reduced velocity compared with wild-type cells

asthenozoospermia ( J:224586 )

• total and progressive spermatozoa motility is reduced compared with wild-type cells

male infertility ( J:224586 )

• male sterility

impaired fertilization ( J:224586 )

• impaired ability of sperm to fertilize oocyte in vitro

cellular

teratozoospermia ( J:224586 )

• many sperm exhibit heads that are bent and wrapped around the next

• spermatozoa from the cauda epididymis lack cytoplasmic droplets

• however, capacitation ability is intact

abnormal sperm annulus morphology ( J:224586 )

• thinning

• with a sharp bend in half of spermatozoa

absent sperm mitochondrial sheath ( J:224586 )

• at the thinned annulus region

decreased sperm progressive motility ( J:224586 )

• progressive spermatozoa exhibit reduced velocity compared with wild-type cells

asthenozoospermia ( J:224586 )

• total and progressive spermatozoa motility is reduced compared with wild-type cells

Allelic Composition	Ccny^tm1.1Smoc/Ccny⁺ Ccnyl1^{tm1a(EUCOMM)Wtsi}/Ccnyl1^{tm1a(EUCOMM)Wtsi}
Genetic Background	involves: C57BL/6N
Cell Lines	EPD0177_5_F06

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnyl1^{tm1a(EUCOMM)Wtsi} mutation (2 available); any Ccnyl1 mutation (17 available)
Ccny^tm1.1Smoc mutation (0 available); any Ccny mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:224586 )

N	• mice are born and survive into adulthood

Allelic Composition	Ccny^tm1.1Smoc/Ccny^tm1.1Smoc Ccnyl1^{tm1a(EUCOMM)Wtsi}/Ccnyl1^{tm1a(EUCOMM)Wtsi}
Genetic Background	involves: C57BL/6N
Cell Lines	EPD0177_5_F06

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:224586 )

Allelic Composition	Ccny^tm1.1Smoc/Ccny^tm1.1Smoc Ccnyl1^{tm1a(EUCOMM)Wtsi}/Ccnyl1⁺
Genetic Background	involves: C57BL/6N
Cell Lines	EPD0177_5_F06

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:224586 )

N	• mice are born and survive into adulthood

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