Phenotypes associated with this allele

• Allele Symbol: Abca8b^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4432962
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abca8b^tm1a(EUCOMM)Wtsi/Abca8b^tm1a(EUCOMM)Wtsi	involves: C57BL/6J * C57BL/6N	MGI:6285119

Genotype
MGI:6285119

hm1

• Allelic Composition: Abca8b^{tm1a(EUCOMM)Wtsi}/Abca8b^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: EPD0454_4_E08

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:269226 )

♂ • on a high-cholesterol diet, mice show reduced total plasma cholesterol levels relative to similarly-fed wild-type controls

decreased circulating HDL cholesterol level ( J:269226 )

♂ • on a high-cholesterol diet, mice show a significant 29% reduction in plasma HDL cholesterol (HDLc) levels relative to similarly-fed wild-type controls

♂ • however, no changes in plasma HDLc levels are observed on a chow diet

decreased circulating LDL cholesterol level ( J:269226 )

♂ • on a high-cholesterol diet, mice show reduced plasma LDL cholesterol levels relative to similarly-fed wild-type controls

decreased circulating triglyceride level ( J:269226 )

♂ • on a high-cholesterol diet, mice show reduced plasma triglyceride levels relative to similarly-fed wild-type controls