Phenotypes associated with this allele

• Allele Symbol: 4933434E20Rik^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4432969
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	4933434E20Rik^tm1a(EUCOMM)Wtsi/4933434E20Rik^tm1a(EUCOMM)Wtsi	C57BL/6N-4933434E20Rik^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5883875
ht2	4933434E20Rik^tm1a(EUCOMM)Wtsi/4933434E20Rik^+	C57BL/6N-4933434E20Rik^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5797325

Genotype
MGI:5883875

hm1

• Allelic Composition: 4933434E20Rik^{tm1a(EUCOMM)Wtsi}/4933434E20Rik^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-4933434E20Rik^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0371_1_D02

Data Sources

IMPC Data for 4933434E20Rik

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

persistent trigeminal artery ( J:239583 )

DMDD

retroesophageal right subclavian artery ( J:239583 )

DMDD

right aortic arch ( J:239583 )

DMDD

absent segment of posterior cerebral artery ( J:239583 )

DMDD

retroesophageal left subclavian artery ( J:239583 )

DMDD

abnormal vertebral artery topology ( J:239583 )

DMDD

abnormal dural venous sinus morphology ( J:239583 )

DMDD

dilated liver sinusoidal space ( J:239583 )

DMDD

abnormal vitelline vein connection ( J:239583 )

DMDD

abnormal ductus venosus valve morphology ( J:239583 )

DMDD

abnormal ductus venosus valve topology ( J:239583 )

DMDD

absent ductus venosus valve ( J:239583 )

DMDD

arteriovenous malformation ( J:239583 )

DMDD

abnormal atrioventricular cushion morphology ( J:239583 )

DMDD

overriding aortic valve ( J:239583 )

DMDD

abnormal heart atrium morphology ( J:239583 )

DMDD

abnormal pectinate muscle morphology ( J:239583 )

DMDD

abnormal heart right atrium morphology ( J:239583 )

DMDD

abnormal inferior vena cava valve morphology ( J:239583 )

DMDD

abnormal interatrial septum morphology ( J:239583 )

DMDD

abnormal heart position or orientation ( J:239583 )

DMDD

perimembraneous ventricular septal defect ( J:239583 )

DMDD

muscular ventricular septal defect ( J:239583 )

DMDD

abnormal aortic valve cusp morphology ( J:239583 )

DMDD

abnormal pulmonary valve cusp morphology ( J:239583 )

DMDD

craniofacial

absent hypoglossal canal ( J:239583 )

DMDD

digestive/alimentary system

anal atresia ( J:239583 )

DMDD

intestinal/bowel diverticulum ( J:239583 )

DMDD

embryo

abnormal vitelline vein connection ( J:239583 )

DMDD

abnormal Mullerian duct morphology ( J:239583 )

DMDD

abnormal Wolffian duct connection ( J:239583 )

DMDD

embryo cyst ( J:239583 )

DMDD

endocrine/exocrine glands

abnormal pineal gland morphology ( J:239583 )

DMDD

absent lobe of thyroid gland ( J:239583 )

DMDD

growth/size/body

embryo cyst ( J:239583 )

DMDD

heterochrony ( J:239583 )

DMDD

homeostasis/metabolism

subcutaneous edema ( J:239583 )

DMDD

immune system

enlarged lymphatic vessel ( J:239583 )

DMDD

blood in lymph vessels ( J:239583 )

DMDD

integument

subcutaneous edema ( J:239583 )

DMDD

liver/biliary system

dilated liver sinusoidal space ( J:239583 )

DMDD

herniated liver ( J:239583 )

DMDD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

muscle

abnormal pectinate muscle morphology ( J:239583 )

DMDD

abnormal eye muscle morphology ( J:239583 )

DMDD

abnormal infrahyoid muscle connection ( J:239583 )

DMDD

nervous system

absent segment of posterior cerebral artery ( J:239583 )

DMDD

abnormal dural venous sinus morphology ( J:239583 )

DMDD

small superior cervical ganglion ( J:239583 )

DMDD

reduced sympathetic cervical ganglion size ( J:239583 )

DMDD

abnormal brain internal capsule morphology ( J:239583 )

DMDD

abnormal forebrain morphology ( J:239583 )

DMDD

abnormal pineal gland morphology ( J:239583 )

DMDD

abnormal cerebral cortex morphology ( J:239583 )

DMDD

abnormal hindbrain morphology ( J:239583 )

DMDD

abnormal hypoglossal nerve topology ( J:239583 )

DMDD

absent hypoglossal nerve ( J:239583 )

DMDD

thin hypoglossal nerve ( J:239583 )

DMDD

fused dorsal root ganglion ( J:239583 )

DMDD

dorsal root ganglion hypoplasia ( J:239583 )

DMDD

renal/urinary system

double ureter ( J:239583 )

DMDD

urinary bladder hypoplasia ( J:239583 )

DMDD

respiratory system

abnormal infrahyoid muscle connection ( J:239583 )

DMDD

abnormal larynx morphology ( J:239583 )

DMDD

skeleton

absent hypoglossal canal ( J:239583 )

DMDD

absent costovertebral joint ( J:239583 )

DMDD

abnormal vertebral arch morphology ( J:239583 )

DMDD

absent vertebral arch ( J:239583 )

DMDD

fusion of vertebral arches ( J:239583 )

DMDD

abnormal vertebral body morphology ( J:239583 )

DMDD

vision/eye

abnormal eye muscle morphology ( J:239583 )

DMDD

abnormal lens morphology ( J:239583 )

DMDD

Genotype
MGI:5797325

ht2

• Allelic Composition: 4933434E20Rik^{tm1a(EUCOMM)Wtsi}/4933434E20Rik⁺
• Genetic Background: C57BL/6N-4933434E20Rik^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0371_1_D02

Data Sources

IMPC Data for 4933434E20Rik

homeostasis/metabolism

decreased circulating fructosamine level ( J:211773 )

♂

IMPC - WTSI

decreased circulating cholesterol level ( J:211773 )

♂

IMPC - WTSI

decreased circulating HDL cholesterol level ( J:211773 )

♂

IMPC - WTSI

increased circulating alanine transaminase level ( J:211773 )

♂

IMPC - WTSI

decreased circulating serum albumin level ( J:211773 )

♂

IMPC - WTSI